NCPR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCPR1_ARATH
• UniProt AC: Q9SB48
• Protein Name: NADPH--cytochrome P450 reductase 1 {ECO:0000255|HAMAP-Rule:MF_03212}
• Gene Name: ATR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 692
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side .
• Protein Description: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and dichloroindophenol..
• Protein Sequence: MTSALYASDLFKQLKSIMGTDSLSDDVVLVIATTSLALVAGFVVLLWKKTTADRSGELKPLMIPKSLMAKDEDDDLDLGSGKTRVSIFFGTQTGTAEGFAKALSEEIKARYEKAAVKVIDLDDYAADDDQYEEKLKKETLAFFCVATYGDGEPTDNAARFYKWFTEENERDIKLQQLAYGVFALGNRQYEHFNKIGIVLDEELCKKGAKRLIEVGLGDDDQSIEDDFNAWKESLWSELDKLLKDEDDKSVATPYTAVIPEYRVVTHDPRFTTQKSMESNVANGNTTIDIHHPCRVDVAVQKELHTHESDRSCIHLEFDISRTGITYETGDHVGVYAENHVEIVEEAGKLLGHSLDLVFSIHADKEDGSPLESAVPPPFPGPCTLGTGLARYADLLNPPRKSALVALAAYATEPSEAEKLKHLTSPDGKDEYSQWIVASQRSLLEVMAAFPSAKPPLGVFFAAIAPRLQPRYYSISSSPRLAPSRVHVTSALVYGPTPTGRIHKGVCSTWMKNAVPAEKSHECSGAPIFIRASNFKLPSNPSTPIVMVGPGTGLAPFRGFLQERMALKEDGEELGSSLLFFGCRNRQMDFIYEDELNNFVDQGVISELIMAFSREGAQKEYVQHKMMEKAAQVWDLIKEEGYLYVCGDAKGMARDVHRTLHTIVQEQEGVSSSEAEAIVKKLQTEGRYLRDVW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSALYASD ------CCHHHHHHH		22223895
80	Phosphorylation	DDDLDLGSGKTRVSI CCCCCCCCCCEEEEE		23111157
249	Phosphorylation	LKDEDDKSVATPYTA HCCCCCCCCCCCCEE		19880383
252	Phosphorylation	EDDKSVATPYTAVIP CCCCCCCCCCEEEEC		27532006
275	Phosphorylation	PRFTTQKSMESNVAN CCCCCHHHHHCCCCC		30291188
278	Phosphorylation	TTQKSMESNVANGNT CCHHHHHCCCCCCCC		23776212
285	Phosphorylation	SNVANGNTTIDIHHP CCCCCCCCEEECCCC		23776212
286	Phosphorylation	NVANGNTTIDIHHPC CCCCCCCEEECCCCC		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCPR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCPR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCPR1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of NCPR1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.