NCLX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCLX_HUMAN
• UniProt AC: Q6J4K2
• Protein Name: Mitochondrial sodium/calcium exchanger protein {ECO:0000305}
• Gene Name: SLC8B1 {ECO:0000312|HGNC:HGNC:26175}
• Organism: Homo sapiens (Human).
• Sequence Length: 584
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. [PubMed: 20018762]
• Protein Sequence: MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	CRKVCGLNVSDRCDF HHHHCCCCHHHCCCE		UniProtKB CARBOHYD
70	Phosphorylation	DRCDFIRTNPDCHSD HCCCEEECCCCCCCC		-
76	Phosphorylation	RTNPDCHSDGGYLDY ECCCCCCCCCCHHHH		-
121	Ubiquitination	LGVTAAKFFCPNLSA HHHHHHHHHCCCHHH		21890473
125	Ubiquitination	AAKFFCPNLSAISTT HHHHHCCCHHHHHHH		22817900
233	Phosphorylation	TLAWALGYLGLYVFY HHHHHHHHHHHHHHH		-
240	Phosphorylation	YLGLYVFYVVTVILC HHHHHHHHHHHHHHH		-
258	Phosphorylation	YQRQRRGSLFCPMPV HHHHHCCCCCCCCCC		23927012
260 (in isoform 2)	Ubiquitination	-		21890473
260	Ubiquitination	RQRRGSLFCPMPVTP HHHCCCCCCCCCCCH		21890473
264	Ubiquitination	GSLFCPMPVTPEILS CCCCCCCCCCHHHCC		22817900
271	Phosphorylation	PVTPEILSDSEEDRV CCCHHHCCCCCCCCC		20873877
273	Phosphorylation	TPEILSDSEEDRVSS CHHHCCCCCCCCCCC		20873877
316 (in isoform 1)	Ubiquitination	-		21890473
316	Ubiquitination	LNPLDYMKWRRKSAY HCHHHHHHHHHHHHH		21890473
320	Ubiquitination	DYMKWRRKSAYWKAL HHHHHHHHHHHHHHH		22817900
341	Phosphorylation	VEFLLLLTVPVVDPD HHHHEEEECCCCCCC		22210691
456	Phosphorylation	VVFRLSNTVLGLTLL HHHHHCCHHHHHHHH		20058876

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
258	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
258	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
258	S	Phosphorylation	Phosphorylation at Ser-258 by PKA prevents calcium overload.	26440884

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCLX_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NCLX_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.