NCKX2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCKX2_RAT
• UniProt AC: O54701
• Protein Name: Sodium/potassium/calcium exchanger 2
• Gene Name: Slc24a2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 670
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)..
• Protein Sequence: MDLHQSATVRLLQEWCSHESPSGCRRHYNTRKKLKLIRVIGLVMGLVAVSTVPFSISAFTETYSQNNRGEASDVTGPRAAPGHRQRTLLDLNDKIRDYTPQPPASQEDRSENGTDHAQGDYPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKVTVSEAQAKASTAGDKEEPTLPNKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCQVDENERQNGAANHVDYAAEKIELPNSTSTEVEMTPSSEASEPVQNGNLSHSIEAADAPQATETAEEDDDQPLSLSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFAFLVVSVLLEDKVLECPVSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	N-linked_Glycosylation	SQEDRSENGTDHAQG CCCHHCCCCCCCCCC	60.97	-
166	Phosphorylation	VPSLTVITEKLGISD CCCHHHHHHHHCCCC	23.80	17038313
302	Ubiquitination	INRNKVVKVTVSEAQ HHCCCCEEEEECHHH	34.87	-
311	Ubiquitination	TVSEAQAKASTAGDK EECHHHHHHHCCCCC	30.69	-
326	Ubiquitination	EEPTLPNKPRLQRGG CCCCCCCCCCCCCCC	29.58	-
334	Phosphorylation	PRLQRGGSSASLHNS CCCCCCCCHHHHHHH	26.09	27097102
335	Phosphorylation	RLQRGGSSASLHNSL CCCCCCCHHHHHHHH	25.75	27097102
337	Phosphorylation	QRGGSSASLHNSLMR CCCCCHHHHHHHHHH	31.91	27097102
341	Phosphorylation	SSASLHNSLMRNSIF CHHHHHHHHHHHHHH	16.88	25403869
365	Phosphorylation	LAEELGSYGKLKYYD HHHHHHHCCCCEEEE	19.24	-
369	Ubiquitination	LGSYGKLKYYDTMTE HHHCCCCEEEECCCC	45.29	-
371	Phosphorylation	SYGKLKYYDTMTEEG HCCCCEEEECCCCCC	11.89	-
476	Phosphorylation	SLSWPSNTRKQITFL CCCCCCCHHHHEEEE	43.51	17038313
504	Phosphorylation	PDVRKPASKKFFPIT CCCCCCCCCCCCCEE	44.92	17038313

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
166	T	Phosphorylation	Kinase	PRKCE	Q02156	GPS
476	T	Phosphorylation	Kinase	PRKCE	Q02156	GPS
504	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCKX2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCKX2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NCKX2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.