dbPTM

NCER2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCER2_ARATH
UniProt AC	Q304B9
Protein Name	Neutral ceramidase 2 {ECO:0000303\|PubMed:26150824}
Gene Name	NCER2 {ECO:0000303\|PubMed:26150824}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	757
Subcellular Localization	Secreted . Endoplasmic reticulum . Golgi apparatus .
Protein Description	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid..
Protein Sequence	MAVSLPLFQFILFLLLLLLSRTVYAYLIGVGSYDITGPAADVNMMGYANSDQIASGIHFRLRARAFIVAEPQGNRVVFVNLDACMASQIVTIKVLERLKARYGELYTEKNVAISGIHTHAGPGGYLQYVTYIVTSLGFVRQSFDVVVNGIEQSIVQAHESLRPGSAFVNKGDLLDAGVNRSPSSYLNNPAAERSKYKYDVDKEMTLVKFVDSQLGPTGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWFENGQKNSVSSRNIPRRVSTIVSDFSRNRDRLLDIAATYKSSRGHSVDKSLDVKTRVRNGSKRKFVSAFCQSNCGDVSPNTLGTFCIDTGLPCDFNHSTCNGQNELCYGRGPGYPDEFESTRIIGEKQFKMAVELFNKATEKLQGKIGYQHAYLDFSNLDVTVPKAGGGSETVKTCPAAMGFGFAAGTTDGPGAFDFKQGDDQGNVFWRLVRNVLRTPGPEQVQCQKPKPILLDTGEMKEPYDWAPSILPIQILRIGQLVILSVPGEFTTMAGRRLRDAIKSFLISSDPKEFSNNMHVVIAGLTNTYSQYIATFEEYEVQRYEGASTLYGRHTLTAYIQEFKKLATALVNGLTLPRGPQPPDLLDKQISLLSPVVVDSTPLGVKFGDVKADVPPKSTFRRGQQVNATFWSGCPRNDLMTEGSFAVVETLREGGKWAPVYDDDDFSLKFKWSRPAKLSSESQATIEWRVPESAVAGVYRIRHYGASKSLFGSISSFSGSSSAFVVV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
311	N-linked_Glycosylation	DVKTRVRNGSKRKFV CHHHCCCCCCCHHHH	-
348	N-linked_Glycosylation	TGLPCDFNHSTCNGQ CCCCCCCCCCCCCCC	-
383	Sulfoxidation	IGEKQFKMAVELFNK CCHHHHHHHHHHHHH	25693801
624	Phosphorylation	DKQISLLSPVVVDST HHHHHHCCCEEEECC	24894044
630	Phosphorylation	LSPVVVDSTPLGVKF CCCEEEECCCCCCCC	24894044
631	Phosphorylation	SPVVVDSTPLGVKFG CCEEEECCCCCCCCC	24894044
657	N-linked_Glycosylation	FRRGQQVNATFWSGC CCCCCEECCEEECCC	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NCER2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCER2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCER2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NCER2_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCER2_ARATH

Related Literatures of Post-Translational Modification