NCDN_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCDN_RAT
• UniProt AC: O35095
• Protein Name: Neurochondrin
• Gene Name: Ncdn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 729
• Subcellular Localization: Cytoplasm, cytosol . Cell projection, dendrite . Localizes to somatic regions of neurons.
• Protein Description: Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth..
• Protein Sequence: MSCCDLAAAGQLGKAGIMASDCEPALNQAESRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELASHPQVLNKIPILCTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLRVGPEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPTTPGPAWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSCCDLAAA ------CCHHHHHHC	24.37	23984901
2	Acetylation	------MSCCDLAAA ------CCHHHHHHC	24.37	-
3	S-palmitoylation	-----MSCCDLAAAG -----CCHHHHHHCC	1.70	23687301
4	S-palmitoylation	----MSCCDLAAAGQ ----CCHHHHHHCCC	3.63	23687301
71	Ubiquitination	KAGDIDAKTRRRIFD HHCCCCHHHHHHHHH	38.52	-
75	Asymmetric dimethylarginine	IDAKTRRRIFDAVGF CCHHHHHHHHHHHCC	30.54	-
75	Methylation	IDAKTRRRIFDAVGF CCHHHHHHHHHHHCC	30.54	-
92	Ubiquitination	PNRLLTTKEAPDGCP CCCCCCCCCCCCCCC	46.79	-
150	Phosphorylation	PDDAARRSMIDDTYQ HHHHHHHHHHCCHHH	17.97	25575281
155	Phosphorylation	RRSMIDDTYQCLTAV HHHHHCCHHHHHHHH	16.25	25575281
156	Phosphorylation	RSMIDDTYQCLTAVA HHHHCCHHHHHHHHC	12.29	25575281
160	Phosphorylation	DDTYQCLTAVAGTPR CCHHHHHHHHCCCCC	27.06	25575281
165	Phosphorylation	CLTAVAGTPRGPRHL HHHHHCCCCCCCCCE	10.48	25575281
272	Acetylation	LARILGSKLSSWQRN HHHHHCCCCHHCCCC	51.06	22902405
272	Ubiquitination	LARILGSKLSSWQRN HHHHHCCCCHHCCCC	51.06	-
275	Phosphorylation	ILGSKLSSWQRNPAL HHCCCCHHCCCCHHH	37.35	22673903
283	Ubiquitination	WQRNPALKLAARLAH CCCCHHHHHHHHHHH	37.88	-
448	Phosphorylation	QVANLAISPTTPGPA HHHHHCCCCCCCCCC	15.58	28551015
450	Phosphorylation	ANLAISPTTPGPAWP HHHCCCCCCCCCCCC	38.54	28551015
451	Phosphorylation	NLAISPTTPGPAWPG HHCCCCCCCCCCCCC	29.63	28551015
483	Ubiquitination	GPREILIKEGAPSLL CCCEEEEECCCHHHH	46.80	-
582	Phosphorylation	LMARLLSTSPALQGT HHHHHHCCCHHHCCC	38.40	25403869
583	Phosphorylation	MARLLSTSPALQGTP HHHHHCCCHHHCCCC	12.56	25403869
717	Phosphorylation	GEETASHYRMAALEQ CHHHHHHHHHHHHHH	10.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCDN_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCDN_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCDN_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NCDN_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.