NCBP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCBP1_SCHPO
• UniProt AC: O14253
• Protein Name: Nuclear cap-binding protein subunit 1
• Gene Name: cbc1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 780
• Subcellular Localization: Cytoplasm, perinuclear region . Nucleus .
• Protein Description: Component of the CBC complex, which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs..
• Protein Sequence: MSSYRGSTRPRKRTREGENYGFRPHRGNSQELLAARIKKDITFLADPRGNSVAADDINYVAMSLSREANDPETISTILDCIQTTAFIIPVKIPHLATLIIRASLRVPLILEKAAAYFCLQYFTNLNSFLYYEAKVDLRMLICMSFALQPGTLKPLFSLLADAISKETKPSVWGDNFLRIILINLPYFIAANNDLGKKDFANEILDQCEIYVRHRKSSITLSNPLSIHDNLSEEELDLLYKQLILSRENDFTFPYISQPWKFFESDFVHIVPVSPSIPEWTFQPTPQQNELPSFKRFFELFNNFEIRTTPDASDVAASIFRDISVDVINHLEFNRVEAAQVLTDLDVYFTYKTFALRGTPVNELPNLDPSESRWKAEDIIVEAVLGELLGSQNTTYKPVYYHSLLIECCRIAPKILAPTFGRVIRLMYTMSSDLPLQTLDRFIDWFSHHLSNFNFHWKWNEWIPDVELDDLHPKKVFMRETITRELILSYYTRISDSLPEELRCLLGEQPSGPNFVYENETHPLYQQSSQIIEALRLHKPLEELDIILQSEEIQNSETSAVRLVMSCAYSLGSRSFSHALNVFEKHLNTLKHFSRKSLDSEIEVVDELFSFWKLQPFNAVMWLDKMLNYSIISITSIIEWLIKQDVTIWSRSYTWSLVNTTFNKLAARLRRSVSNKEDSSLINEANEEKEIVTNLLLSALRALISENAENIWVSHWLNLMLKYVESNFLSVKKDTIEEANEPVQENTSEEQEDTKMQPVDAVDEQPSENNQTAADATNEEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	FRPHRGNSQELLAAR CCCCCCCHHHHHHHH	28.05	28889911
671	Phosphorylation	LAARLRRSVSNKEDS HHHHHHHHHCCCCCC	24.38	24763107
673	Phosphorylation	ARLRRSVSNKEDSSL HHHHHHHCCCCCCHH	43.35	24763107
746	Phosphorylation	NEPVQENTSEEQEDT CCCCCCCCCHHHCCC	36.44	25720772
747	Phosphorylation	EPVQENTSEEQEDTK CCCCCCCCHHHCCCC	51.20	25720772
766	Phosphorylation	DAVDEQPSENNQTAA CCCCCCCCCCCCCCC	53.29	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCBP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCBP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCBP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YE02_SCHPO	mtl1	physical	25989903
YLP3_SCHPO	red1	physical	25989903
YGK8_SCHPO	pir2	physical	25989903
NCBP2_SCHPO	cbc2	physical	25989903
MMI1_SCHPO	mmi1	physical	25989903

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29, AND MASSSPECTROMETRY.
PubMed: 18257517