NCAM1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCAM1_RAT
• UniProt AC: P13596
• Protein Name: Neural cell adhesion molecule 1
• Gene Name: Ncam1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 858
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc..
• Protein Sequence: MLRTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEEAWHSKWYDAKEANMEGIVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKTQPVREPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRALASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVETKSEPQESEAKPAPTEVKTVPNEATQTKENESKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	N-linked_Glycosylation	QARQSIVNATANLGQ HHHHHHHHHHCCCCC	29.88	-
267	Phosphorylation	DDEKHIFSDDSSELT CCCCCCCCCCCCCEE	39.65	21630457
270	Phosphorylation	KHIFSDDSSELTIRN CCCCCCCCCCEEEEE	30.61	30240740
271	Phosphorylation	HIFSDDSSELTIRNV CCCCCCCCCEEEEEC	43.55	30240740
316	N-linked_Glycosylation	PKITYVENQTAMELE CEEEEEECCEEEEEE	34.16	-
348	N-linked_Glycosylation	TWRTSTRNISSEEKA EEEECCCCCCHHHHC	38.28	-
434	N-linked_Glycosylation	TWEGNQVNITCEVFA EECCCEEEEEEEEEE	17.68	-
460	N-linked_Glycosylation	GQLLPSSNYSNIKIY CCCCCCCCCCCEEEE	48.90	-
489	N-linked_Glycosylation	ENDFGNYNCTAVNRI CCCCCCCCCCCEEEC	22.21	-
648	Acetylation	PIRHYLVKYRALASE CCHHHHHHHHHHHHC	26.82	22902405
657	Acetylation	RALASEWKPEIRLPS HHHHHCCCCCEECCC	28.81	22902405
694	Acetylation	ENQQGKSKAAHFVFR ECCCCCCCEEEEEEE	53.75	22902405
744	Phosphorylation	VVMDITCYFLNKCGL HHHHHHHHHHHHCCH	11.49	20605779
770	Ubiquitination	AGPGAKGKDMEEGKA CCCCCCCCCHHHHHC	53.87	-
776	Ubiquitination	GKDMEEGKAAFSKDE CCCHHHHHCCCCCCC	39.56	-
780	Phosphorylation	EEGKAAFSKDESKEP HHHHCCCCCCCCCCC	34.17	30411139
784	Phosphorylation	AAFSKDESKEPIVEV CCCCCCCCCCCCEEE	53.07	23712012
785	Ubiquitination	AFSKDESKEPIVEVR CCCCCCCCCCCEEEE	66.51	-
793	Phosphorylation	EPIVEVRTEEERTPN CCCEEEECCCCCCCC	53.58	30240740
798	Phosphorylation	VRTEEERTPNHDGGK EECCCCCCCCCCCCC	31.55	30240740
807	Phosphorylation	NHDGGKHTEPNETTP CCCCCCCCCCCCCCC	57.53	30240740
812	Phosphorylation	KHTEPNETTPLTEPE CCCCCCCCCCCCCCC	40.11	30240740
813	Phosphorylation	HTEPNETTPLTEPEK CCCCCCCCCCCCCCC	15.32	30240740
816	Phosphorylation	PNETTPLTEPEKGPV CCCCCCCCCCCCCCC	51.18	30240740
820	Ubiquitination	TPLTEPEKGPVETKS CCCCCCCCCCCCCCC	78.29	-
825	Phosphorylation	PEKGPVETKSEPQES CCCCCCCCCCCCCCC	39.85	30240740
826	Ubiquitination	EKGPVETKSEPQESE CCCCCCCCCCCCCCC	39.04	-
827	Phosphorylation	KGPVETKSEPQESEA CCCCCCCCCCCCCCC	63.03	30240740
835	Ubiquitination	EPQESEAKPAPTEVK CCCCCCCCCCCCCCC	37.35	-
852	Ubiquitination	PNEATQTKENESKA- CCCCCCCHHHHCCC-	49.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
744	Y	Phosphorylation	Kinase	NTRK2	Q63604	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCAM1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCAM1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBB_RAT	Ubb	physical	17971410

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.