| UniProt ID | NB5R4_HUMAN | |
|---|---|---|
| UniProt AC | Q7L1T6 | |
| Protein Name | Cytochrome b5 reductase 4 | |
| Gene Name | CYB5R4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 521 | |
| Subcellular Localization | Endoplasmic reticulum . Soluble protein. | |
| Protein Description | NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.. | |
| Protein Sequence | MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESMLKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPSTHLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLFTPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MLNVPSQS -------CCCCCCCC | 5.76 | 22814378 | |
| 6 | Phosphorylation | --MLNVPSQSFPAPR --CCCCCCCCCCCCH | 33.89 | 26503514 | |
| 8 | Phosphorylation | MLNVPSQSFPAPRSQ CCCCCCCCCCCCHHH | 37.22 | 24043423 | |
| 14 | Phosphorylation | QSFPAPRSQQRVASG CCCCCCHHHCCHHCC | 29.61 | 22617229 | |
| 154 | Phosphorylation | LNGMLPKSQVTDTLA HCCCCCHHHHHHHHH | 28.13 | 19664995 | |
| 157 | Phosphorylation | MLPKSQVTDTLAKEG CCCHHHHHHHHHHHC | 18.68 | 19664995 | |
| 277 | Ubiquitination | DTGLYYRKCQLISKE CCCCEEEEEEEECCC | 15.37 | 29967540 | |
| 282 | Phosphorylation | YRKCQLISKEDVTHD EEEEEEECCCCCCCC | 38.29 | 24719451 | |
| 326 | Phosphorylation | GTEIVKPYTPVSGSL CCEECCCCCCCCCCH | 20.25 | - | |
| 361 | Phosphorylation | IYPTGLFTPELDRLQ ECCCCCCCCCCCCCE | 22.39 | - | |
| 418 | Phosphorylation | YALTDIPSLRKVKLM HHHCCCCCCCEEEEE | 40.93 | 24719451 | |
| 430 | Phosphorylation | KLMFFNKTEDDIIWR EEEEEECCCCCHHHH | 45.83 | 29083192 | |
| 442 | Ubiquitination | IWRSQLEKLAFKDKR HHHHHHHHHHCCCCC | 54.42 | 29967540 | |
| 471 | Phosphorylation | NGKQGHISPALLSEF CCCCCCCCHHHHHHH | 9.84 | - | |
| 476 | Phosphorylation | HISPALLSEFLKRNL CCCHHHHHHHHHHCC | 27.44 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NB5R4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NB5R4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NB5R4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NB5R4_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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