dbPTM

NASP_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NASP_DROME
UniProt AC	Q9I7K6
Protein Name	Protein NASP homolog
Gene Name	CG8223
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	492
Subcellular Localization
Protein Description
Protein Sequence	MSAEAEAIVTTATADVSSPSKTVAVEPVAADTTPDNAPAVSTEGSGKAEQERAEKILKGKELFSQGSRNFLVKSYDEAADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMALDENKVIDVPDEAADDDDEDVDDDEEESAEDGAAKKEEKKDTKEAANGASSSNGKELDTIKEGSDEADSTGEAEQAQSDEKPSKKVPTGVDEVSSSNGGGGAAVNDDERPSTSNGEVTASCSNGAAPAVEEEPEEEEGVSGSLQLAWEILEAAAQIFSRQGLSGLPYLAEVQTELANIEFENGILEAAREDYEKALKIHGELPTRNRRALAELHYKIGLTYLMQQLNKEGATALRQSSVLIEEEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEIEEMQAQTIAEVRAALDSYIKPMSSGDAAAASSSSSSSANGAASSSSSSSKGAAAASSSTISSSSAKPTDITHLIKRKKPEDPSSEAEALCSPAKRAAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAEAEAIV ------CCHHHCEEE	34.51	19429919
10	Phosphorylation	AEAEAIVTTATADVS HHHCEEEEECCCCCC	12.47	19429919
11	Phosphorylation	EAEAIVTTATADVSS HHCEEEEECCCCCCC	15.89	19429919
13	Phosphorylation	EAIVTTATADVSSPS CEEEEECCCCCCCCC	22.69	19429919
17	Phosphorylation	TTATADVSSPSKTVA EECCCCCCCCCCEEE	36.76	19429919
18	Phosphorylation	TATADVSSPSKTVAV ECCCCCCCCCCEEEE	32.80	19429919
20	Phosphorylation	TADVSSPSKTVAVEP CCCCCCCCCEEEEEE	42.79	19429919
22	Phosphorylation	DVSSPSKTVAVEPVA CCCCCCCEEEEEEEC	20.31	28490779
32	Phosphorylation	VEPVAADTTPDNAPA EEEECCCCCCCCCCC	35.19	28490779
33	Phosphorylation	EPVAADTTPDNAPAV EEECCCCCCCCCCCC	29.23	22817900
42	Phosphorylation	DNAPAVSTEGSGKAE CCCCCCCCCCCCHHH	37.45	30478224
47	Acetylation	VSTEGSGKAEQERAE CCCCCCCHHHHHHHH	50.91	21791702
143	Phosphorylation	VDDDEEESAEDGAAK CCCCHHHHHHHHHHH	39.99	19429919
165	Phosphorylation	KEAANGASSSNGKEL HHHHHCCCCCCCCCC	35.38	22668510
166	Phosphorylation	EAANGASSSNGKELD HHHHCCCCCCCCCCC	27.56	22668510
170	Acetylation	GASSSNGKELDTIKE CCCCCCCCCCCCCCC	60.39	21791702
174	Phosphorylation	SNGKELDTIKEGSDE CCCCCCCCCCCCCCC	46.72	19429919
179	Phosphorylation	LDTIKEGSDEADSTG CCCCCCCCCCCCCCC	33.11	21082442
184	Phosphorylation	EGSDEADSTGEAEQA CCCCCCCCCCHHHHH	45.41	21082442
185	Phosphorylation	GSDEADSTGEAEQAQ CCCCCCCCCHHHHHH	39.32	19429919
193	Phosphorylation	GEAEQAQSDEKPSKK CHHHHHHCCCCCCCC	51.24	18327897
198	Phosphorylation	AQSDEKPSKKVPTGV HHCCCCCCCCCCCCC	57.06	23607784
451	Phosphorylation	KGAAAASSSTISSSS HCCCHHCCCCCCCCC	27.12	21082442
452	Phosphorylation	GAAAASSSTISSSSA CCCHHCCCCCCCCCC	27.54	21082442
455	Phosphorylation	AASSSTISSSSAKPT HHCCCCCCCCCCCCC	25.02	21082442
456	Phosphorylation	ASSSTISSSSAKPTD HCCCCCCCCCCCCCC	25.18	22817900
460	Acetylation	TISSSSAKPTDITHL CCCCCCCCCCCHHHH	50.85	21791702
469	Acetylation	TDITHLIKRKKPEDP CCHHHHHHCCCCCCC	65.61	21791702
477	Phosphorylation	RKKPEDPSSEAEALC CCCCCCCCHHHHHHC	53.80	19429919
478	Phosphorylation	KKPEDPSSEAEALCS CCCCCCCHHHHHHCC	46.33	19429919
485	Phosphorylation	SEAEALCSPAKRAAV HHHHHHCCHHHHHCC	28.83	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NASP_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NASP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NASP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RS27A_DROME	RpS27A	physical	24292889

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NASP_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-32; THR-33; SER-179;SER-184; THR-185; SER-193; SER-478 AND SER-485, AND MASS SPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485, AND MASSSPECTROMETRY.	17372656 [Abstract]