NAGS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAGS_HUMAN
• UniProt AC: Q8N159
• Protein Name: N-acetylglutamate synthase, mitochondrial
• Gene Name: NAGS
• Organism: Homo sapiens (Human).
• Sequence Length: 534
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity..
• Protein Sequence: MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLSTAWSQPQPPPEEYAGADDVSQSPVAEEPSWVPSPRPPVPHESPEPPSGRSLVQRDIQAFLNQCGASPGEARHWLTQFQTCHHSADKPFAVIEVDEEVLKCQQGVSSLAFALAFLQRMDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYNAAAILTMEPVLGGTPYLDKFVVSSSRQGQGSGQMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	TGGARRLSCGARRRA CCCHHHCCHHHHHHH	14.53	24114839
283	Ubiquitination	EVTASLAKALRPTKI HHHHHHHHHHCCEEE	53.93	-
356	Phosphorylation	AVITAASTLLTELFS HHHHHHHHHHHHHHC	22.51	-
359	Phosphorylation	TAASTLLTELFSNKG HHHHHHHHHHHCCCC	33.48	-
382	Phosphorylation	ERMLRVRSLDKLDQG HHHHHHCCHHHCCCC	37.75	22798277
410	Phosphorylation	LRDDYLASLRPRLHS HHHHHHHHHCHHCEE	23.47	24719451
424	Phosphorylation	SIYVSEGYNAAAILT EEEECCCCCEEEEEE	9.51	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAGS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAGS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAGS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NAGS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 237310: N-acetylglutamate synthase deficiency (NAGSD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.