dbPTM

NAF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NAF1_SCHPO
UniProt AC	O14360
Protein Name	H/ACA ribonucleoprotein complex non-core subunit NAF1
Gene Name	naf1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	516
Subcellular Localization	Nucleus. Absent from the nucleolus..
Protein Description	RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex (By similarity)..
Protein Sequence	MYPHLPCKIPGLSLIYDDESKVEKSKQLSTNASSSNFVKEDQIPSNLSIDNINTPQGDPIDKNNLNTNTENNLPNIVNFQNISSANSGEIKQKDNEILFSSTEDINQHKENYQDENKIDLLDVALANPKDCVVPSSGLLMPKEEFISNEEVGIPATNSSEKSNVKIADEIAEVTHSNSSIGKSSADLSSDSSSDSESNTSFSETDVEEEKAEEKSDAESMAPSTPPKTVNELPEQIYEKPEIVLQPNSLIEPLGKIIQVLKREVVVKSDIDDEKIVFDEKTVLCFEDRSIIGYIHETFGPVSSPYYIVRFSTEEECSAINACMGRPVFYVPTMANKIDPEPLKYIKGSDASNVYDEEINPSEQEFSDDEAEVAAKQLKKKRKRKAKSMVSGNQALPGEANFQSLNQNNVRNYPFYQTNQGSNPPAKRFTQEPPSSSLYSLSESSINYSTQSPMYYNYNYPQPSFPPFHPIYNDSIGYYSQANPQMYYANQVSAPPPQGSFDPNSKFYRNSSDSYRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	VKEDQIPSNLSIDNI CCHHCCCCCCCCCCC	52.62	29996109
48	Phosphorylation	DQIPSNLSIDNINTP HCCCCCCCCCCCCCC	31.95	21712547
100	Phosphorylation	KDNEILFSSTEDINQ CCCEEEECCHHHHHH	32.67	24763107
101	Phosphorylation	DNEILFSSTEDINQH CCEEEECCHHHHHHH	28.60	21712547
102	Phosphorylation	NEILFSSTEDINQHK CEEEECCHHHHHHHH	36.16	24763107
176	Phosphorylation	EIAEVTHSNSSIGKS HHHHHCCCCCCCCCC	29.10	19547744
215	Phosphorylation	EEKAEEKSDAESMAP HHHHHHHCHHHHHCC	45.38	24763107
219	Phosphorylation	EEKSDAESMAPSTPP HHHCHHHHHCCCCCC	23.20	24763107
223	Phosphorylation	DAESMAPSTPPKTVN HHHHHCCCCCCCCHH	43.97	24763107
224	Phosphorylation	AESMAPSTPPKTVNE HHHHCCCCCCCCHHH	42.42	28889911
361	Phosphorylation	YDEEINPSEQEFSDD CCCCCCCCCCCCCHH	47.63	28889911
366	Phosphorylation	NPSEQEFSDDEAEVA CCCCCCCCHHHHHHH	43.32	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NAF1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NAF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NAF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NAF1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NAF1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361 AND SER-366, ANDMASS SPECTROMETRY.	18257517 [Abstract]