dbPTM

NAC2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NAC2_RAT
UniProt AC	P48768
Protein Name	Sodium/calcium exchanger 2
Gene Name	Slc8a2
Organism	Rattus norvegicus (Rat).
Sequence Length	921
Subcellular Localization	Cell membrane Multi-pass membrane protein . Basolateral cell membrane Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, dendritic spine .
Protein Description	Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. [PubMed: 8021246]
Protein Sequence	MAPLALVGVALLLGAPHCLGEATPTPSLPPPPANDSDASPGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGLSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPSCFDYVMHFLTVFWKVLFACLPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWFLYILFASLEAYCHIRGF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	N-linked_Glycosylation	SLPPPPANDSDASPG CCCCCCCCCCCCCCC	55.91	-
111	Ubiquitination	EKEITITKANGETSV CCEEEEEEECCCEEE	35.68	-
394	Phosphorylation	DDEDDGASRIFFEPS CCCCCCHHHEECCHH	31.29	25403869
503	Acetylation	PDGGGRPKGRLVAPL CCCCCCCCCCCHHHC	56.13	25786129
537	S-nitrosocysteine	RLLHVSECMGTVDVR HHCCHHHHCCEEEEE	2.07	-
537	S-nitrosylation	RLLHVSECMGTVDVR HHCCHHHHCCEEEEE	2.07	22178444
594	Ubiquitination	TMKTLQVKIVDDEEY CEEEEEEEECCHHHH	24.85	-
622	Phosphorylation	QWLKRGISALLLNQG HHHHHHHHHHHCCCC	18.71	30411139
634	Ubiquitination	NQGDGDRKLTAEEEE CCCCCCCCCCHHHHH	55.73	-
675	Ubiquitination	DFKNTVDKLIKKTNL CCCHHHHHHHHHCCE	48.01	-
713	Phosphorylation	EEEDEDGSREERLPS CCCCCCCCHHHCCHH	49.17	28551015
817	N-linked_Glycosylation	CADASIGNVTGSNAV HCCCCCCCCCCCCHH	26.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NAC2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NAC2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NAC2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NAC2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NAC2_RAT

Related Literatures of Post-Translational Modification