N4BP1_MOUSE - dbPTM
N4BP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID N4BP1_MOUSE
UniProt AC Q6A037
Protein Name NEDD4-binding protein 1
Gene Name N4bp1
Organism Mus musculus (Mouse).
Sequence Length 893
Subcellular Localization Nucleus, nucleolus. Nucleus, PML body. Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated.
Protein Description Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates..
Protein Sequence MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGALGAEEPLPARIWLQLRGAQEAVHSAKEYIKGICEPELEEKECYPKAMHCIFVGAQSLFLKSLIQDTCADLCVLDTGLLGIRGSAEAVVMARSHIQQFVKLFESNENLPSNQRESEIKREFRQFVEAHADSYTMDLLILPTSLKKELLSLTQGEESLFETDDDVITVGDVRPPEYTQSAATGPSSARDEVVVQEDSRNKARTPVSELTKHMDTVFSSSPDVLFVPVNGLSPDEDALSKDRVCHKRRSSDTEERHTKKQFSLENVPEGELLPDGKGSAGNEVIDLSDPASNSTNLSPDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQEDRDFPPCTVYPDASQSRNAGVGSTTNELTADSTPKKAQSHTEQSMVERFSQLPFKDSKHCTSNCKVNSFRTVPVGQKQEIWGSKQNSSCTVDLETDGHSASAASASPKDISFVSRGASGHQQRNPAFPENGFQQQTEPLLPNNTKPACEKRSGSCSSPQPKPNYPPLSPPLPLPQLLPSVTEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNITEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRLLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEAFLRHMQPLLNALPSVGTFDPGFRSPSTQVANNSHQPPPRIQTSSSPWLPQQSHFTALATLPSMQQNPPLPAQRSSAETSELREALLKIFPDSEQKLKIDQILAAHPYMKDLNALSALVLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationRVVLDEFTAPAEKAA
EEECCCCCCHHHHHH		29.68-
241PhosphorylationDSRNKARTPVSELTK
CCCCCCCCCHHHHHH		32.6626824392
244PhosphorylationNKARTPVSELTKHMD
CCCCCCHHHHHHHHH		28.2625159016
248UbiquitinationTPVSELTKHMDTVFS
CCHHHHHHHHHHHHH		49.94-
255PhosphorylationKHMDTVFSSSPDVLF
HHHHHHHHCCCCEEE		26.1025338131
257PhosphorylationMDTVFSSSPDVLFVP
HHHHHHCCCCEEEEE		24.7425338131
269PhosphorylationFVPVNGLSPDEDALS
EEECCCCCCCHHHHC		31.5319060867
276PhosphorylationSPDEDALSKDRVCHK
CCCHHHHCCCCCCCC		33.9423984901
286PhosphorylationRVCHKRRSSDTEERH
CCCCCCCCCCHHHHH		36.2825266776
287PhosphorylationVCHKRRSSDTEERHT
CCCCCCCCCHHHHHH		46.9025266776
296UbiquitinationTEERHTKKQFSLENV
HHHHHHHHCCCCCCC		58.70-
299PhosphorylationRHTKKQFSLENVPEG
HHHHHCCCCCCCCCC		32.0725521595
324PhosphorylationGNEVIDLSDPASNST
CCCEEECCCCCCCCC		37.4925619855
328PhosphorylationIDLSDPASNSTNLSP
EECCCCCCCCCCCCC		36.3826643407
330PhosphorylationLSDPASNSTNLSPDG
CCCCCCCCCCCCCCC		19.0425619855
331PhosphorylationSDPASNSTNLSPDGK
CCCCCCCCCCCCCCC		44.4225619855
334PhosphorylationASNSTNLSPDGKDTT
CCCCCCCCCCCCCCC		24.0225619855
340PhosphorylationLSPDGKDTTEEMEYN
CCCCCCCCCHHHHHH		39.3226643407
341PhosphorylationSPDGKDTTEEMEYNI
CCCCCCCCHHHHHHH		39.8326643407
346PhosphorylationDTTEEMEYNILVNFF
CCCHHHHHHHHHHHH		13.2426643407
415PhosphorylationSRNAGVGSTTNELTA
CCCCCCCCCCCCCCC		29.6525619855
416PhosphorylationRNAGVGSTTNELTAD
CCCCCCCCCCCCCCC		27.9325619855
417PhosphorylationNAGVGSTTNELTADS
CCCCCCCCCCCCCCC		28.5225619855
421PhosphorylationGSTTNELTADSTPKK
CCCCCCCCCCCCCHH		23.4125619855
424PhosphorylationTNELTADSTPKKAQS
CCCCCCCCCCHHHHH		44.1125619855
425PhosphorylationNELTADSTPKKAQSH
CCCCCCCCCHHHHHC		39.4125619855
447UbiquitinationRFSQLPFKDSKHCTS
HHHCCCCCCCCCCCC		60.18-
460PhosphorylationTSNCKVNSFRTVPVG
CCCCEECCCEEEECC		21.0624719451
493PhosphorylationETDGHSASAASASPK
CCCCCCCCCCCCCHH		27.6425619855
496PhosphorylationGHSASAASASPKDIS
CCCCCCCCCCHHHCE		29.0625619855
498PhosphorylationSASAASASPKDISFV
CCCCCCCCHHHCEEE		29.9525619855
500UbiquitinationSAASASPKDISFVSR
CCCCCCHHHCEEECC		66.26-
503PhosphorylationSASPKDISFVSRGAS
CCCHHHCEEECCCCC		29.7222006019
542UbiquitinationNTKPACEKRSGSCSS
CCCCCCCCCCCCCCC		52.31-
544PhosphorylationKPACEKRSGSCSSPQ
CCCCCCCCCCCCCCC		46.2425619855
546PhosphorylationACEKRSGSCSSPQPK
CCCCCCCCCCCCCCC		16.4525619855
548PhosphorylationEKRSGSCSSPQPKPN
CCCCCCCCCCCCCCC		46.9125619855
549PhosphorylationKRSGSCSSPQPKPNY
CCCCCCCCCCCCCCC		31.7026824392
556PhosphorylationSPQPKPNYPPLSPPL
CCCCCCCCCCCCCCC		18.1125619855
560PhosphorylationKPNYPPLSPPLPLPQ
CCCCCCCCCCCCHHH		30.1926824392
571PhosphorylationPLPQLLPSVTEARLG
CHHHCCCCCCCHHHC		41.4625619855
573PhosphorylationPQLLPSVTEARLGGS
HHCCCCCCCHHHCCC		28.4125619855
580PhosphorylationTEARLGGSSDHIDSS
CCHHHCCCCCCCCCC		30.6926643407
581PhosphorylationEARLGGSSDHIDSSV
CHHHCCCCCCCCCCC		36.1626643407
847PhosphorylationPPLPAQRSSAETSEL
CCCCCCCCCCCHHHH		23.0922871156
851PhosphorylationAQRSSAETSELREAL
CCCCCCCHHHHHHHH		27.5022871156
852PhosphorylationQRSSAETSELREALL
CCCCCCHHHHHHHHH		26.5822871156
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of N4BP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of N4BP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of N4BP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of N4BP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of N4BP1_MOUSE

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Related Literatures of Post-Translational Modification

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