MYT1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYT1L_HUMAN
• UniProt AC: Q9UL68
• Protein Name: Myelin transcription factor 1-like protein {ECO:0000303|Ref.1}
• Gene Name: MYT1L {ECO:0000303|Ref.1, ECO:0000312|HGNC:HGNC:7623}
• Organism: Homo sapiens (Human).
• Sequence Length: 1186
• Subcellular Localization: Nucleus . Chromosome . Preferentially binds to DNA binding sites that are in an open chromatin configuration.
• Protein Description: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes..
• Protein Sequence: MEVDTEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENMNDRNYADSMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQERNPQQNMNIRQHVRPEEDFPGRTPDRNYSDMLNLMRLEEQLSPRSRVFASCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMEAGRRDNMRSYEDQSPRQLPGEDRKPKSSDSHVKKPYYGKDPSRTEKKESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHESVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSSQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCATRNPDMEVDENGTLDLSMNKQRPRDSCCPILTPLEPMSPQQQAVMNNRCFQLGEGDCWDLPVDYTKMKPRRIDEDESKDITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
221	Phosphorylation	DAAYRARTESEMNSN HHHHHHHCHHHHCCC	42.76	-
223	Phosphorylation	AYRARTESEMNSNTS HHHHHCHHHHCCCCC	41.34	-
237	Phosphorylation	SNSLEDDSDKNENLG CCCCCCCCCCCCCCC	63.91	-
250	Phosphorylation	LGRKSELSLDLDSDV CCCHHHHHCCCCHHH	18.78	-
325	Phosphorylation	SDEEVCLSSLECLRN CCHHHHHHHHHHHHH	27.96	22817900
342	Phosphorylation	FDLARKLSETNPQER HHHHHHHHHCCCCCC	45.47	22817900
390	Phosphorylation	MRLEEQLSPRSRVFA HHHHHHCCCCHHHHH	20.26	27732954
442	Phosphorylation	EKAIALETERAKAMR HHHHHHHHHHHHHHH	31.46	24114839
464	Phosphorylation	GRRDNMRSYEDQSPR HCHHCHHCCCCCCCC	23.31	28122231
465	Phosphorylation	RRDNMRSYEDQSPRQ CHHCHHCCCCCCCCC	17.11	28122231
469	Phosphorylation	MRSYEDQSPRQLPGE HHCCCCCCCCCCCCC	34.08	28122231
526	Phosphorylation	GLYPHHRSLSGCPHK CCCCCCCCCCCCCCC	23.64	27251275
528	Phosphorylation	YPHHRSLSGCPHKDR CCCCCCCCCCCCCCC	39.33	27251275
570	Phosphorylation	SNRNSHRSLSGCPIA CCCCCCCCCCCCHHH	22.82	27732954
572	Phosphorylation	RNSHRSLSGCPIAAA CCCCCCCCCCHHHHH	39.33	27732954
619	Phosphorylation	KQLEIPQYGYRNNVP EEECCCCCCCCCCCC	15.69	25262027
621	Phosphorylation	LEIPQYGYRNNVPTT ECCCCCCCCCCCCCC	12.77	25262027
632	Phosphorylation	VPTTTPRSNLAKELE CCCCCCCCHHHHHHH	37.08	-
641	Phosphorylation	LAKELEKYSKTSFEY HHHHHHHHCCCCCEE	13.16	24129246
642	Phosphorylation	AKELEKYSKTSFEYN HHHHHHHCCCCCEEC	40.29	24129246
644	Phosphorylation	ELEKYSKTSFEYNSY HHHHHCCCCCEECCC	32.48	24129246
645	Phosphorylation	LEKYSKTSFEYNSYD HHHHCCCCCEECCCC	21.59	24129246
648	Phosphorylation	YSKTSFEYNSYDNHT HCCCCCEECCCCCCC	13.85	29759185
650	Phosphorylation	KTSFEYNSYDNHTYG CCCCEECCCCCCCCC	32.72	24129246
651	Phosphorylation	TSFEYNSYDNHTYGK CCCEECCCCCCCCCC	19.68	29759185
655	Phosphorylation	YNSYDNHTYGKRAIA ECCCCCCCCCCCCCC	39.98	24129246
656	Phosphorylation	NSYDNHTYGKRAIAP CCCCCCCCCCCCCCC	17.07	24129246
689	Phosphorylation	CKDPSPSSSSTSSYA CCCCCCCCCCCCCCC	31.52	-
694	Phosphorylation	PSSSSTSSYAPSSSS CCCCCCCCCCCCCCC	25.96	-
699	Phosphorylation	TSSYAPSSSSNLSCG CCCCCCCCCCCCCCC	36.41	-
704	Phosphorylation	PSSSSNLSCGGGSSA CCCCCCCCCCCCCCC	18.24	-
709	Phosphorylation	NLSCGGGSSASSTCS CCCCCCCCCCCCCCC	26.46	-
712	Phosphorylation	CGGGSSASSTCSKSS CCCCCCCCCCCCCCC	28.29	-
716	Phosphorylation	SSASSTCSKSSFDYT CCCCCCCCCCCCCCC	35.34	-
734	Phosphorylation	EAAHMAATAILNLST HHHHHHHHHHHHHHH	12.51	-
753	Acetylation	MPQNLSTKPQDLCAT CCCCCCCCHHHHCCC	36.99	7667007
854	Phosphorylation	FQEALEERRYPGEVT HHHHHHHCCCCCCCC	33.77	24719451
856	Phosphorylation	EALEERRYPGEVTIP HHHHHCCCCCCCCCC	23.08	24719451
859	Phosphorylation	EERRYPGEVTIPSPK HHCCCCCCCCCCCCC	31.80	24719451
861	Phosphorylation	RRYPGEVTIPSPKPK CCCCCCCCCCCCCCC	23.91	24719451
864	Phosphorylation	PGEVTIPSPKPKYPQ CCCCCCCCCCCCCCC	41.53	24117733
869	Phosphorylation	IPSPKPKYPQCKESK CCCCCCCCCCCCCCC	13.68	-
875	Phosphorylation	KYPQCKESKKDLITL CCCCCCCCCCCEEEE	30.42	-
925	Phosphorylation	GNYASHRSLSGCPRA CCCCCCCCCCCCCCH	22.82	-
1006	Phosphorylation	SVKTEGMSCPTPGCD ECEECCCCCCCCCCC	28.00	30576142
1009	Phosphorylation	TEGMSCPTPGCDGSG ECCCCCCCCCCCCCC	36.32	30576142
1015	Phosphorylation	PTPGCDGSGHVSGSF CCCCCCCCCCCCCCC	16.69	24043423
1019	Phosphorylation	CDGSGHVSGSFLTHR CCCCCCCCCCCCCCC	24.05	24043423
1021	Phosphorylation	GSGHVSGSFLTHRSL CCCCCCCCCCCCCCC	15.02	24043423
1024	Phosphorylation	HVSGSFLTHRSLSGC CCCCCCCCCCCCCCC	17.15	30576142
1044	Phosphorylation	AMKKAKLSGEQMLTI HHHHHCCCCCCCHHH	39.31	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYT1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYT1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYT1L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYT1L_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.