MYRIP_HUMAN - dbPTM
MYRIP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYRIP_HUMAN
UniProt AC Q8NFW9
Protein Name Rab effector MyRIP
Gene Name MYRIP
Organism Homo sapiens (Human).
Sequence Length 859
Subcellular Localization Cytoplasm . Cytoplasm, perinuclear region . Cytoplasmic vesicle, secretory vesicle . In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalize
Protein Description Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity)..
Protein Sequence MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELEDAARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTRRRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKERKGTTKDLMEPALESAVMY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationKLDLSGLTDDETEHV
CCCCCCCCCCCHHHH		44.9527732954
48PhosphorylationQKLDEEGSKCSILSK
HHHHHCCCCCCHHHH		33.4922817900
51PhosphorylationDEEGSKCSILSKHQQ
HHCCCCCCHHHHHHH		30.2422817900
54PhosphorylationGSKCSILSKHQQFVE
CCCCCHHHHHHHHHH		26.8222817900
142PhosphorylationAKVLKNLYRKHRLES
HHHHHHHHHHHCCCC		27.32-
170O-linked_GlycosylationSNLENEGSISGSDST
CCCCCCCCCCCCCCC		13.8528411811
172O-linked_GlycosylationLENEGSISGSDSTFY
CCCCCCCCCCCCCEE		33.6628411811
174O-linked_GlycosylationNEGSISGSDSTFYRQ
CCCCCCCCCCCEEEC		22.9228411811
176O-linked_GlycosylationGSISGSDSTFYRQSE
CCCCCCCCCEEECCC		23.3228411811
186PhosphorylationYRQSEGHSVMDTLAV
EECCCCCCHHHHHHH		29.9622210691
207PhosphorylationEAIEEAISKAEAYGD
HHHHHHHHHHHHHCH		32.6322210691
277PhosphorylationTKVADEGTSASPGGY
CEECCCCCCCCCCCC		21.0527732954
278PhosphorylationKVADEGTSASPGGYR
EECCCCCCCCCCCCC		37.2927732954
280PhosphorylationADEGTSASPGGYRAP
CCCCCCCCCCCCCCC		24.6823403867
284PhosphorylationTSASPGGYRAPAALW
CCCCCCCCCCCHHHH		14.9823403867
293PhosphorylationAPAALWRSQSAFSIT
CCHHHHCCCCCCCCC		19.5323403867
295PhosphorylationAALWRSQSAFSITGE
HHHHCCCCCCCCCCH		32.3123403867
298PhosphorylationWRSQSAFSITGEEAL
HCCCCCCCCCCHHHH		20.9623403867
300PhosphorylationSQSAFSITGEEALKT
CCCCCCCCCHHHHCC		37.0227732954
307PhosphorylationTGEEALKTPPVEAPS
CCHHHHCCCCCCCCC		33.4027732954
314PhosphorylationTPPVEAPSRQPRDQG
CCCCCCCCCCCCCCC		51.0727732954
335PhosphorylationSALPSWKSVDRLDET
HCCCCCCCCCCCCCC		24.0026657352
342PhosphorylationSVDRLDETNLAPVLQ
CCCCCCCCCCCCCEE		34.8926657352
350PhosphorylationNLAPVLQSPDGNWVA
CCCCCEECCCCCEEE		22.3124076635
414PhosphorylationLSKLCPRSRALPRNP
HHHHCHHHCCCCCCC		13.6723909892
445PhosphorylationASPSSALSPNPEAMC
CCCCCCCCCCCCCCC		23.5022798277
504PhosphorylationNFNPQLASRETSDSS
CCCHHHHCCCCCCCC		38.9622210691
507PhosphorylationPQLASRETSDSSEPE
HHHHCCCCCCCCCCC		36.4030177828
508PhosphorylationQLASRETSDSSEPEE
HHHCCCCCCCCCCCC		30.6430177828
510PhosphorylationASRETSDSSEPEEAP
HCCCCCCCCCCCCCC		36.0525072903
511PhosphorylationSRETSDSSEPEEAPH
CCCCCCCCCCCCCCC		63.2624275569
519PhosphorylationEPEEAPHTTDRRARR
CCCCCCCCHHHHHHH		29.3622210691
520PhosphorylationPEEAPHTTDRRARRW
CCCCCCCHHHHHHHH		25.1922210691
534PhosphorylationWRRARLGSEEPSKEP
HHHHHCCCCCCCCCC		43.2923403867
538PhosphorylationRLGSEEPSKEPSSPS
HCCCCCCCCCCCCCC		53.5926657352
542PhosphorylationEEPSKEPSSPSAQLR
CCCCCCCCCCCHHHH		56.8423403867
543PhosphorylationEPSKEPSSPSAQLRD
CCCCCCCCCCHHHHC		33.3223403867
545PhosphorylationSKEPSSPSAQLRDLD
CCCCCCCCHHHHCCC		30.5123403867
553PhosphorylationAQLRDLDTHQVSDDL
HHHHCCCHHCCCCCC		22.8525072903
557PhosphorylationDLDTHQVSDDLSETD
CCCHHCCCCCCCCCC		20.8826657352
561PhosphorylationHQVSDDLSETDISNE
HCCCCCCCCCCCCCC		45.5026657352
563PhosphorylationVSDDLSETDISNEAR
CCCCCCCCCCCCCCC		34.9428192239
566PhosphorylationDLSETDISNEARDPQ
CCCCCCCCCCCCCCC		31.2825072903
588PhosphorylationEKRRNRLYELAMKMS
HHHHHHHHHHHHHHH		12.9827642862
611PhosphorylationDQESEPKTESENQKE
CCCCCCCCCCHHHHH		56.30-
613PhosphorylationESEPKTESENQKESL
CCCCCCCCHHHHHHC		47.26-
638PhosphorylationEELKKKFSAVSLCNI
HHHHHHHCHHHHHCC		36.3228348404
788O-linked_GlycosylationRRDQKQRTQVQTIDT
CCCHHHHHHCEEECC		30.5128411811
792O-linked_GlycosylationKQRTQVQTIDTSRQQ
HHHHHCEEECCHHHH		23.2028411811
816O-linked_GlycosylationKAEKIETSSVTTIKT
CHHHCCCCCEEEEEE		15.2628411811
817O-linked_GlycosylationAEKIETSSVTTIKTF
HHHCCCCCEEEEEEE		30.7928411811
844PhosphorylationRTKERKGTTKDLMEP
CCCCCCCCCHHHHHH		33.44-
845PhosphorylationTKERKGTTKDLMEPA
CCCCCCCCHHHHHHH		31.09-
859PhosphorylationALESAVMY-------
HHHHHHCC-------		14.59-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYRIP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYRIP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYRIP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CA216_HUMANC1orf216physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYRIP_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; SER-51 AND SER-54,AND MASS SPECTROMETRY.

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