MYPR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYPR_RAT
• UniProt AC: P60203
• Protein Name: Myelin proteolipid protein
• Gene Name: Plp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 277
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Myelin membrane. Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat..
• Protein Description: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin..
• Protein Sequence: MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	S-palmitoylation	--MGLLECCARCLVG --CCHHHHHHHHHCC	1.91	-
7	S-palmitoylation	-MGLLECCARCLVGA -CCHHHHHHHHHCCC	1.63	-
10	S-palmitoylation	LLECCARCLVGAPFA HHHHHHHHHCCCHHH	1.60	-
50	Phosphorylation	TEKLIETYFSKNYQD HHHHHHHHHCCCCCC	7.96	-
105	Acetylation	RQIFGDYKTTICGKG HHHHCCCCEEEECCC	43.88	22902405
105	Ubiquitination	RQIFGDYKTTICGKG HHHHCCCCEEEECCC	43.88	-
109	S-palmitoylation	GDYKTTICGKGLSAT CCCCEEEECCCEEEE	4.29	-
111	Ubiquitination	YKTTICGKGLSATVT CCEEEECCCEEEEEC	52.87	-
114	Phosphorylation	TICGKGLSATVTGGQ EEECCCEEEEECCCC	30.48	25403869
116	Phosphorylation	CGKGLSATVTGGQKG ECCCEEEEECCCCCC	18.41	25403869
118	Phosphorylation	KGLSATVTGGQKGRG CCEEEEECCCCCCCC	31.10	25403869
122	Acetylation	ATVTGGQKGRGSRGQ EEECCCCCCCCCCCH	54.58	13583995
122	Ubiquitination	ATVTGGQKGRGSRGQ EEECCCCCCCCCCCH	54.58	-
134	Phosphorylation	RGQHQAHSLERVCHC CCHHHHHHHHHHHHH	34.63	25403869
139	S-palmitoylation	AHSLERVCHCLGKWL HHHHHHHHHHHHHHC	2.05	-
141	S-palmitoylation	SLERVCHCLGKWLGH HHHHHHHHHHHHCCC	4.54	-
199	O-palmitoylation	KTSASIGSLCADARM CCCCCHHHHHHHHHH	20.71	-
201	S-nitrosylation	SASIGSLCADARMYG CCCHHHHHHHHHHHC	3.27	22178444
201	S-nitrosocysteine	SASIGSLCADARMYG CCCHHHHHHHHHHHC	3.27	-
207	Phosphorylation	LCADARMYGVLPWNA HHHHHHHHCCCCCCC	9.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYPR_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYPR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYPR_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MYPR_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.