MYOM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOM1_HUMAN
• UniProt AC: P52179
• Protein Name: Myomesin-1
• Gene Name: MYOM1
• Organism: Homo sapiens (Human).
• Sequence Length: 1685
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, M line.
• Protein Description: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent..
• Protein Sequence: MSLPFYQRCHQHYDLSYRNKDVRSTVSHYQREKKRSAVYTQGSTAYSSRSSAAHRRESEAFRRASASSSQQQASQHALSSEVSRKAASAYDYGSSHGLTDSSLLLDDYSSKLSPKPKRAKHSLLSGEEKENLPSDYMVPIFSGRQKHVSGITDTEEERIKEAAAYIAQRNLLASEEGITTSKQSTASKQTTASKQSTASKQSTASKQSTASRQSTASRQSVVSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMHTLEINGCDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIGGGVSPDVCPALSDEPGGLTASRGRVHEASPPTFQKDALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPPPQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVVAETRPGTKEVVVNVDDDGVISLNFECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDLGMDDLGIYSCDVTDTDGIASSYLIDEEELKRLLALSHEHKFPTVPVKSELAVEILEKGQVRFWMQAEKLSGNAKVNYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKATNHSTVVLVGDVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGEQIWLQINEPTPNDKGKYVMELFDGKTGHQKTVDLSGQAYDEAYAEFQRLKQAAIAEKNRARVLGGLPDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLKGGKKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPFYQRC ------CCCCHHHHH	56.93	22673903
13	Phosphorylation	YQRCHQHYDLSYRNK HHHHHHHCCCCCCCC	16.41	-
24	Phosphorylation	YRNKDVRSTVSHYQR CCCCCHHHHHHHHHH	32.77	26437602
25	Phosphorylation	RNKDVRSTVSHYQRE CCCCHHHHHHHHHHH	18.57	26437602
27	Phosphorylation	KDVRSTVSHYQREKK CCHHHHHHHHHHHHH	19.30	26437602
29	Phosphorylation	VRSTVSHYQREKKRS HHHHHHHHHHHHHCC	11.19	-
36	Phosphorylation	YQREKKRSAVYTQGS HHHHHHCCCEEECCC	30.85	25072903
39	Phosphorylation	EKKRSAVYTQGSTAY HHHCCCEEECCCCCC	7.96	24043423
40	Phosphorylation	KKRSAVYTQGSTAYS HHCCCEEECCCCCCC	21.61	25072903
43	Phosphorylation	SAVYTQGSTAYSSRS CCEEECCCCCCCCCC	10.47	25072903
44	Phosphorylation	AVYTQGSTAYSSRSS CEEECCCCCCCCCCH	36.12	25072903
46	Phosphorylation	YTQGSTAYSSRSSAA EECCCCCCCCCCHHH	13.78	24043423
47	Phosphorylation	TQGSTAYSSRSSAAH ECCCCCCCCCCHHHH	19.46	25072903
48	Phosphorylation	QGSTAYSSRSSAAHR CCCCCCCCCCHHHHH	24.41	25072903
50	Phosphorylation	STAYSSRSSAAHRRE CCCCCCCCHHHHHHH	26.69	26437602
58	Phosphorylation	SAAHRRESEAFRRAS HHHHHHHHHHHHHHH	32.20	26437602
65	Phosphorylation	SEAFRRASASSSQQQ HHHHHHHHCCCHHHH	27.20	19764811
67	Phosphorylation	AFRRASASSSQQQAS HHHHHHCCCHHHHHH	28.20	22673903
68	Phosphorylation	FRRASASSSQQQASQ HHHHHCCCHHHHHHH	31.70	26437602
69	Phosphorylation	RRASASSSQQQASQH HHHHCCCHHHHHHHH	29.52	19764811
79	Phosphorylation	QASQHALSSEVSRKA HHHHHHHHHHHHHHH	25.82	26437602
80	Phosphorylation	ASQHALSSEVSRKAA HHHHHHHHHHHHHHH	42.75	26437602
101	Phosphorylation	SSHGLTDSSLLLDDY CCCCCCCHHHHCCCH	20.04	22210691
113	Phosphorylation	DDYSSKLSPKPKRAK CCHHCCCCCCCCHHH	34.31	26437602
122	Phosphorylation	KPKRAKHSLLSGEEK CCCHHHCCCCCCCCC	30.24	26437602
125	Phosphorylation	RAKHSLLSGEEKENL HHHCCCCCCCCCCCC	49.83	26437602
134	Phosphorylation	EEKENLPSDYMVPIF CCCCCCCCCCEEEEE	44.53	26074081
136	Phosphorylation	KENLPSDYMVPIFSG CCCCCCCCEEEEECC	12.35	26074081
142	Phosphorylation	DYMVPIFSGRQKHVS CCEEEEECCCCCCCC	33.51	26074081
149	Phosphorylation	SGRQKHVSGITDTEE CCCCCCCCCCCCCHH	24.97	26437602
152	Phosphorylation	QKHVSGITDTEEERI CCCCCCCCCCHHHHH	40.15	26437602
154	Phosphorylation	HVSGITDTEEERIKE CCCCCCCCHHHHHHH	36.32	26437602
174	Phosphorylation	AQRNLLASEEGITTS HHHHHHCCCCCCCCC	35.83	22673903
179	Phosphorylation	LASEEGITTSKQSTA HCCCCCCCCCCCCCC	35.55	22673903
180	Phosphorylation	ASEEGITTSKQSTAS CCCCCCCCCCCCCCC	31.82	22673903
220	Phosphorylation	QSTASRQSVVSKQAT HHHHHHHHHHHHHHH	24.31	26437602
227	Phosphorylation	SVVSKQATSALQQEE HHHHHHHHHHHHHHH	16.43	26437602
236	Phosphorylation	ALQQEETSEKKSRKV HHHHHHHCCHHHCCH	51.18	26437602
253	Phosphorylation	REKAERLSLRKTLEE HHHHHHHCHHHHHHH	32.14	23532336
257	Phosphorylation	ERLSLRKTLEETETY HHHCHHHHHHHHHHH	32.73	26437602
261	Phosphorylation	LRKTLEETETYHAKL HHHHHHHHHHHHHHC	25.01	26437602
285	Phosphorylation	EFIIKPRSHTVWEKE EEEECCCCCCCEEEC	31.85	26437602
287	Phosphorylation	IIKPRSHTVWEKENV EECCCCCCCEEECCE	28.67	26437602
309	Phosphorylation	GWPEPRVTWYKNQVP CCCCCCEEEEECCEE	25.10	-
311	Phosphorylation	PEPRVTWYKNQVPIN CCCCEEEEECCEEEE	7.24	-
336	Phosphorylation	ESRYGMHTLEINGCD EECCCEEEEEECCCC	19.73	22210691
347	Phosphorylation	NGCDFEDTAQYRASA CCCCCCCCHHHHHHC	14.41	22210691
350	Phosphorylation	DFEDTAQYRASAMNV CCCCCHHHHHHCCCC	12.99	22210691
362	O-linked_Glycosylation	MNVKGELSAYASVVV CCCCCCHHHEEEEEE	18.22	30379171
372	Phosphorylation	ASVVVKRYKGEFDET EEEEEEECCCCCCCC	20.02	26437602
379	Phosphorylation	YKGEFDETRFHAGAS CCCCCCCCEEECCCC	40.24	30174305
386	Phosphorylation	TRFHAGASTMPLSFG CEEECCCCCCCEEEC	25.07	30174305
387	Phosphorylation	RFHAGASTMPLSFGV EEECCCCCCCEEECC	23.44	30174305
391	Phosphorylation	GASTMPLSFGVTPYG CCCCCCEEECCCCCC	17.68	30174305
397	Phosphorylation	LSFGVTPYGYASRFE EEECCCCCCEEEEEE	17.25	30174305
399	Phosphorylation	FGVTPYGYASRFEIH ECCCCCCEEEEEEEE	8.78	30174305
401	Phosphorylation	VTPYGYASRFEIHFD CCCCCEEEEEEEEEC	29.08	30174305
423	Phosphorylation	GREGETMSLGCRVVI CCCCCCEEEEEEEEE	29.09	26437602
444	Phosphorylation	FQPEIQWYRNGVPLS CCCCCCHHHCCCCCC	4.28	26437602
451	Phosphorylation	YRNGVPLSPSKWVQT HHCCCCCCHHHHHHH	22.51	9029142
458	Phosphorylation	SPSKWVQTLWSGERA CHHHHHHHHHCCCCE	22.15	22673903
466	Phosphorylation	LWSGERATLTFSHLN HHCCCCEEEEEECCC	32.33	26437602
470	Phosphorylation	ERATLTFSHLNKEDE CCEEEEEECCCCCCC	23.10	26437602
481	Phosphorylation	KEDEGLYTIRVRMGE CCCCCEEEEEEECCC	13.83	24719451
482	Phosphorylation	EDEGLYTIRVRMGEY CCCCEEEEEEECCCC	2.12	9029142
572	Phosphorylation	KFARFPVTGLIEGRS EEEECEECCEECCCE	26.89	22673903
579	Phosphorylation	TGLIEGRSYIFRVRA CCEECCCEEEEEEEE	33.18	22673903
580	Phosphorylation	GLIEGRSYIFRVRAV CEECCCEEEEEEEEE	11.61	22673903
615	Phosphorylation	AEKARLKSRPSAPWT HHHHHHHCCCCCCCC	54.75	26437602
618	Phosphorylation	ARLKSRPSAPWTGQI HHHHCCCCCCCCCEE	45.94	26437602
694	Phosphorylation	NTELPVKSPRFALFD CCCCCCCCCEEEEEE	22.88	26437602
708	Phosphorylation	DLAEGKSYCFRVRCS EECCCCEEEEEEEEC	10.09	-
715	Phosphorylation	YCFRVRCSNSAGVGE EEEEEEECCCCCCCC	24.21	24114839
724	Phosphorylation	SAGVGEPSEATEVTV CCCCCCCCCCEEEEE	35.24	24114839
753	Phosphorylation	IPSRNTDTSVVVSWE CCCCCCCCEEEEEEE	22.76	22673903
754	Phosphorylation	PSRNTDTSVVVSWEE CCCCCCCEEEEEEEC	18.74	22673903
794	Phosphorylation	NNNPVKGSRFTCHGL CCCCCCCCCEEEEEE	20.64	26437602
797	Phosphorylation	PVKGSRFTCHGLVTG CCCCCCEEEEEEECC	11.50	26437602
839 (in isoform 2)	Phosphorylation	-	9.44	26437602
877	Phosphorylation	QKDALLGSKPNKPSL CHHCCCCCCCCCCCC	44.93	26437602
883	Phosphorylation	GSKPNKPSLPSSSQN CCCCCCCCCCCCCCC	55.30	-
887	Phosphorylation	NKPSLPSSSQNLGQT CCCCCCCCCCCCCCC	33.72	-
966	Phosphorylation	KIGGAEITGYYVNYR CCCCEEEEEEEEEHH	15.61	24719451
969	Phosphorylation	GAEITGYYVNYREVI CEEEEEEEEEHHHHC	5.42	24719451
992	Phosphorylation	EANVKAVSEEAYKIS HHHHHHHCHHHHHHH	34.28	26437602
996	Phosphorylation	KAVSEEAYKISNLKE HHHCHHHHHHHCCCH	16.48	26437602
999	Phosphorylation	SEEAYKISNLKENMV CHHHHHHHCCCHHHH	31.77	26437602
1044	Phosphorylation	AVPGPPHSLKCSEVR ECCCCCCCCCCCHHC	34.98	26437602
1054	Phosphorylation	CSEVRKDSLVLQWKP CCHHCCCCEEEEECC	24.34	26437602
1065	Phosphorylation	QWKPPVHSGRTPVTG EECCCCCCCCCCCEE	30.15	26437602
1083	Acetylation	DLKEAKAKEDQWRGL EHHHHHCCCCCCCCC	62.20	12429875
1110	Phosphorylation	RGLKEGVSYVFRVRA CCCCCCEEEEEEEEE	26.83	26437602
1111	Phosphorylation	GLKEGVSYVFRVRAI CCCCCEEEEEEEEEE	10.95	24719451
1170	Phosphorylation	MTPKSEFSWSKDYVS CCCCCCCCCCCCCCC	26.79	22673903
1172	Phosphorylation	PKSEFSWSKDYVSTE CCCCCCCCCCCCCCC	17.91	22673903
1177	Phosphorylation	SWSKDYVSTEDSPRL CCCCCCCCCCCCCCE	21.61	26437602
1178	Phosphorylation	WSKDYVSTEDSPRLE CCCCCCCCCCCCCEE	33.49	22673903
1181	Phosphorylation	DYVSTEDSPRLEVES CCCCCCCCCCEEEEE	12.99	26437602
1270	Phosphorylation	WMQAEKLSGNAKVNY EEEEEHHCCCCEEEE	40.86	26437602
1277	Phosphorylation	SGNAKVNYIFNEKEI CCCCEEEEEECCHHH	15.18	25884760
1290	Phosphorylation	EIFEGPKYKMHIDRN HHHCCCCEEEEEECC	19.37	26074081
1298	Phosphorylation	KMHIDRNTGIIEMFM EEEEECCCCHHHHHH	30.56	26074081
1392	Phosphorylation	KETHIVWYKDEREIS EEEEEEEECCCCEEC	9.54	-
1399	Phosphorylation	YKDEREISVDEKHDF ECCCCEECCCCCCCC	20.82	26437602
1426	Phosphorylation	SKKDAGIYEVILKDD CCCCCCEEEEEEECC	11.83	25147952
1462	Phosphorylation	VCKKIALSATDLKIQ HHHHHHHCCCCCEEE	21.79	22673903
1464	Phosphorylation	KKIALSATDLKIQST HHHHHCCCCCEEEEC	38.19	22673903
1493	Phosphorylation	EDLKVNWSHNGSAIR EECEEECCCCCCEEE	11.23	26437602
1497	Phosphorylation	VNWSHNGSAIRYSDR EECCCCCCEEEECCC	26.32	26437602
1551	Phosphorylation	VDLSGQAYDEAYAEF EECCCCCHHHHHHHH	13.36	-
1555	Phosphorylation	GQAYDEAYAEFQRLK CCCHHHHHHHHHHHH	12.48	-
1615	Phosphorylation	KNEKALASDDHCNLK HCCCCCCCCCCCCEE	44.41	26437602
1632	Phosphorylation	AGRTAYFTINGVSTA CCCEEEEEECCEECC	10.80	22210691
1644	Phosphorylation	STADSGKYGLVVKNK ECCCCCCEEEEEEEC	21.15	22210691
1677	Phosphorylation	ARMAALESLKGGKKA HHHHHHHHHCCCCCC	35.91	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
482	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
618	S	Phosphorylation	Kinase	PRKACA	P36887	GPS
618	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOM1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYOM1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.