MYO5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO5_ARATH
• UniProt AC: Q39160
• Protein Name: Myosin-5
• Gene Name: XI-1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1520
• Subcellular Localization: Cytoplasm . Colocalizes with peroxisome, cytoplasmic vesicles and/or organelles.
• Protein Description: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Contributes to the trafficking of Golgi stacks, mitochondria and peroxisomes. Required for development of pavement cells, trichomes, and stigmatic papillae..
• Protein Sequence: MAAPVIIVGSHVWVEDPHLAWIDGEVTRIDGINVHVKTKKGKTVVTNVYFPKDTEAPSGGVDDMTKLSYLHEPGVLRNLETRYELNEIYTYTGNILIAVNPFQRLPHIYETDMMEQYKGIALGELSPHVFAIGDAAYRAMINEGKNNSILVSGESGAGKTETTKMLMRYLAFLGGRSGVEGRTVEQQVLESNPVLEAFGNAKTLRNNNSSRFGKFVEIQFDKNGRISGAAIRTYLLERSRVCQISDPERNYHCFYLLCAAPPEDIKKYKLENPHKFHYLNQSSCYKLDGVDDASEYLETRRAMDVVGISNEEQEAIFRVVAAILHLGNIDFGKGEEIDSSVIKDKDSRSHLNMAAELLMCNAQSLEDALIRRVMVTPEEIITRTLDPDNAIASRDTLAKTIYSHLFDWIVNKINTSIGQDPRSKSIIGVLDIYGFESFKCNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEEIAWSYIEFIDNQDVLELIEKKPGGIISLLDEACMFPKSTHETFSQKLFQTFKEHERFAKPKLSRTDFTISHYAGEVTYQSNHFIDKNKDYIVAEHQALFTASNCKFVAGLFHALHEDSSRSSKFSSIGSRFKQQLHSLMESLNGTEPHYIRCIKPNNVLKPGIFENFNVIHQLRCGGVLEAIRISCAGYPTRLAFYDFLDRFGLLAPEVLEGNYDDKVACQMILDKKSLTDYQIGKTKIFLRAGQMAELDARRAEVLGNAARVIQRQFRTCMARKNYRSIRNAAIVLQSFLRGEIARAVHKKLRIEAAALRVQKNFRRYVDRKSFVTTRSSTIVLQTGLRAMIARSEFRLRRQRKAAIVLQAHWRGRQAFSYYTRLQKAAIVTQCAWRCRLARRELRMLKMAARDTGALKDAKNKLEQRVEELSLRLHLEKRLRTDLEEAKVQEVAKLQEALHTMRLQLKETTAMVVKEQEAARVAIEEASSVNKEPVVVEDTEKIDSLSNEIDRLKGLLSSETHKADEAQHAYQSALVQNEELCKKLEEAGRKIDQLQDSVQRFQEKVFSLESENKVLRQQTLTISPTTRALALRPKTTIIQRTPEKDTFSNGETTQLQEPETEDRPQKSLNQKQQENQELLLKSISEDIGFSEGKPVAACLIYKCLIHWRSFEVERTSIFNRIIETIASAIEMQENSDVLCYWLSNSATLLMFLQRTLKAGATGSITTPRRRGMPSSLFGRVSQSFRGSPQSAGFPFMTGRAIGGGLDELRQVEAKYPALLFKQQLTAFLEKIYGMIRDKMKKEISPLLASCIQVPRTPRSGLVKGRSQNTQNNVVAPKPMIAHWQNIVTCLNGHLRTMRANYVPSLLISKVFGQIFSFINVQLFNSLLLRRECCSFSNGEYVKTGLAELEKWCHDATEEFVGSAWDELKHIRQAVGFLVIHQKPKKSLKEITTELCPVLSIQQLYRISTMYWDDKYGTHSVSTEVIATMRAEVSDVSKSAISNSFLLDDDSSIPFSLDDISKSMQNVEVAEVDPPPLIRQNSNFMFLLERSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	Phosphorylation	ISGAAIRTYLLERSR CCHHHHHHHHHHHCC		19880383
239	Phosphorylation	RTYLLERSRVCQISD HHHHHHHCCCCCCCC		24894044
502	Phosphorylation	KKPGGIISLLDEACM HCCCCEEECCHHHHC		22074104
1052	Phosphorylation	RQQTLTISPTTRALA HHCEEEECCCCHHHH		25561503
1054	Phosphorylation	QTLTISPTTRALALR CEEEECCCCHHHHCC		25561503
1195	Phosphorylation	GATGSITTPRRRGMP CCCCCCCCCCCCCCC		25561503
1210	Phosphorylation	SSLFGRVSQSFRGSP HHHHHHHCHHCCCCC		28295753
1212	Phosphorylation	LFGRVSQSFRGSPQS HHHHHCHHCCCCCCC		28295753
1510	Phosphorylation	PPLIRQNSNFMFLLE CCCCCCCCCEEEEEE		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP1_ARATH	DCP1	physical	24525673

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.