MYO1D_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO1D_RAT
• UniProt AC: Q63357
• Protein Name: Unconventional myosin-Id
• Gene Name: Myo1d
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1006
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)..
• Protein Sequence: MAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKVLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIMISGESGAGKTEASKYIMQYIAAITNPSQRAEIERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLHSLHLQKSLSSYNYIRVGAQLKSSINDAAEFKVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFIVDGDTPLIENGKVVSVIAELLSTKADMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTVHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDGMFLEALNSKLGKHGHFSSRKTCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLVRVVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHGVKNMRDYGKHVKWPTPPKVLRRFEEALQSIFNRWRASQLIKTIPASDLPQVRAKVAAMEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFHTKDNKDLIVCLFSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHGKKCTVSVETRLNQPQPDFTKNRSGFILSVPGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEQESLEF ------CCCHHHHHC	38.18	-
35	Acetylation	NLRLRFEKGRIYTFI HHHHEECCCCEEEEE	51.26	72588745
200	Phosphorylation	VQQPGERSFHSFYQL EECCCCCCHHHHHHH	24.02	-
238	Ubiquitination	IRVGAQLKSSINDAA CEECCCHHHCCCCHH	30.03	-
260	Acetylation	AMKVIGFKPEEIQTV HHHHHCCCHHHHHHH	46.43	22902405
478	Acetylation	FLEALNSKLGKHGHF HHHHHHHHCCCCCCC	61.25	22902405
524	Acetylation	IGFIDKNKDTLFQDF EEEECCCCCCHHHHH	58.80	22902405
536	Phosphorylation	QDFKRLMYNSSNPVL HHHHHHHHCCCCHHH	19.24	-
551	Ubiquitination	KNMWPEGKLSITEVT HHCCCCCCCCEEEEC	37.08	-
553	Phosphorylation	MWPEGKLSITEVTKR CCCCCCCCEEEECCC	30.83	28432305
555	Phosphorylation	PEGKLSITEVTKRPL CCCCCCEEEECCCCC	22.49	28432305
571	Phosphorylation	AATLFKNSMIALVDN HHHHCCCCHHHHHHH	16.50	28432305
634	Acetylation	AFRQTYEKFLHRYKM HHHHHHHHHHHHHHC	42.69	22902405
660	Acetylation	PSDKEAVKKLIERCG CCCHHHHHHHHHHHC	49.24	22902405
758	Ubiquitination	KNMRDYGKHVKWPTP CCHHHCCCCCCCCCC	38.71	-
786	Phosphorylation	IFNRWRASQLIKTIP HHHHHCHHHHHHHCC	19.56	22673903
886	Acetylation	VTDRHLYKMDPTKQY EECCCCCCCCCCCCE	43.09	22902405
890	Phosphorylation	HLYKMDPTKQYKVMK CCCCCCCCCCEEEEE	26.90	25575281
893	Phosphorylation	KMDPTKQYKVMKTIP CCCCCCCEEEEEECE	13.70	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO1D_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO1D_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO1D_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO1D_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.