MYO17_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO17_ARATH
• UniProt AC: F4K5J1
• Protein Name: Myosin-17
• Gene Name: XI-K
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1531
• Subcellular Localization: Cytoplasm . Colocalizes with peroxisome, cytoplasmic vesicles, endomembrane vesicles, endoplasmic reticulum and/or organelles.
• Protein Description: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in the tip growth of root hair cells and in the elongation of trichome stalk and branches. Plays a major role in trafficking of Golgi stacks, mitochondria and peroxisomes during root hair development. Acts as the primary contributor to ER streaming with a major role in the movement of Golgi bodies. Required for development of pavement cells, trichomes, and stigmatic papillae..
• Protein Sequence: MVGPVNIIVGSHVWIEDPGAAWIDGEVVKINGEEVHAHTTNGKTVVANIANVFPKDTEAPPGGVDDMTKLSYLHEPGVLNNLAMRYELNEIYTYTGNILIAVNPFQRLPHLYDTHMMEQYKGAGFGELSPHVFAIAEVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRSGVEGRTVEQQVLESNPVLEAFGNAKTLRNNNSSRFGKFVELQFDNCGRISGAAVRTYLLERSRVCQISDPERNYHCFYLLCAAPPEEREKFKLGDPKLFHYLNQSKCYKLDGVDDTEEYLATRRAMDIVGISEEEQDAIFRVVAAILHLGNVNFAKGKEIDSSVLKDEKSRYHLDVCAELLRCDAKKMEDALIKRVMVTPEEVITRTLDPDSATGSRDALAKTIYSRLFDWLVDKINNSIGQDPNSKTIIGVLDIYGFESFKINSFEQFCINFTNEKLQQHFNQHVFKMEQEDYTKEEINWSYIEFVDNKDVLELIEKKPGGVIALLDEACMFPKSTHETFAQKLYQTFKNYKRFTKPKLSRTSFAISHYAGEVTYQADLFLDKNKDYVVAEHQDLLIASSDTFVAGLFPRLPEETSSKTKFSSIGSRFKLQLQSLMETLSSTEPHYIRCVKPNNVLKPAIFENVNVIQQLRCGGVLEAIRISCAGYPTKRTFYEFLNRFGVLAPEVLEGNYDDKVACKMLLDKIGLKGYELGKTKVFLRAGQMAELDARRAEVLGNAARRIQRQSRTFIACKEFRALRGAAIVLQSNCRGKLACNLYEEMRRQAAAVKIQKIFRRHIARESYLRIRHSTITVQTALRGMVARNEFRFRKQMKAATIIQARLRSHLTHSYYKQLQKAALSTQCGWRSRVARKELRTLKMAARDTGALREAKDKLEKRVEELTWRLQLEKRQRTELEEAKTQEYAKQQEALETMRLQVEEANAAVIREREAARKAIEEAPPVIKETPVLVEDTEKINSLTSEVEALKASLQAERQAAENLRKAFSEAEARNSELATELENATRKADQLHESVQRLEEKLSNSESEIQVLRQQALAISPTSRTMATRSKTMLLPRTPENGNYLNGGTKTTPDMTLAVREPESEEKPQKHLNEKQQENQDLLVKCISQNLGYNGDKPVAACVIYKCLLHWRSFEVERTSVFDRIIQTIATAIEVPDNNEVLAYWLSNSATLLLLLQRTLKATGAASLTPQRRRTTSASLFGRMSQGLRGSPQSAGLSFLNRQGLTKLDDLRQVEAKYPALLFKQQLTAFLEKIYGMIRDNLKKEISPLLGLCIQAPRTSRASLVKGRAQANAVAQQALIAHWQSIRKSLNSYLNLMKANNAPPFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLAELEQWCIEATDEYAGSAWDELRHIRQAVGFLVIHQKPKKTLDEITRELCPVLSIQQLYRISTMYWDDKYGTHSVSSDVIANMRVMMTEDSNNAVSSSFLLDDDSSIPFTVEDISKSMQQVDVNDIEPPQLIRENSGFGFLLTRKEGSTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
242	Phosphorylation	RTYLLERSRVCQISD HHHHHHHCCCCCCCC		24894044
1056	Phosphorylation	RQQALAISPTSRTMA HHHHHHCCCCCCCCC		30291188
1058	Phosphorylation	QALAISPTSRTMATR HHHHCCCCCCCCCCC		23776212
1059	Phosphorylation	ALAISPTSRTMATRS HHHCCCCCCCCCCCC		23776212
1068	Phosphorylation	TMATRSKTMLLPRTP CCCCCCCCEEECCCC		23111157
1080	Phosphorylation	RTPENGNYLNGGTKT CCCCCCCCCCCCCCC		22074104
1085	Phosphorylation	GNYLNGGTKTTPDMT CCCCCCCCCCCCCCE		22074104
1199	Phosphorylation	LQRTLKATGAASLTP HHHHHHHHCCCCCCC		29797451
1211	Phosphorylation	LTPQRRRTTSASLFG CCCCCCCCCCHHHHH		29654922
1212	Phosphorylation	TPQRRRTTSASLFGR CCCCCCCCCHHHHHH		25561503
1213	Phosphorylation	PQRRRTTSASLFGRM CCCCCCCCHHHHHHH		25561503
1215	Phosphorylation	RRRTTSASLFGRMSQ CCCCCCHHHHHHHCC		29797451
1230	Phosphorylation	GLRGSPQSAGLSFLN CCCCCCCHHCCHHHH		23776212
1234	Phosphorylation	SPQSAGLSFLNRQGL CCCHHCCHHHHHCCC		30291188
1517	Phosphorylation	PQLIRENSGFGFLLT CHHHHCCCCCCEEEE		30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO17_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO17_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO17_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MD37A_ARATH	BIP1	physical	20351265
DCP1_ARATH	DCP1	physical	24525673

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.