MYL1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYL1_RAT
• UniProt AC: P02600
• Protein Name: Myosin light chain 1/3, skeletal muscle isoform
• Gene Name: Myl1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 189
• Protein Description: Regulatory light chain of myosin. Does not bind calcium..
• Protein Sequence: MAPKKDVKKPAAAAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKEQQEEFKEAFLLFDRTGECKITLSQVGDVLRALGTNPTNAEVKKVLGNPSNEEMNAKKIEFEQFLPMMQAISNNKDQGGYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALLAGQEDSNGCINYEAFVKHIMSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MAPKKDVKK ------CCCHHHCCC	25.31	-
2 (in isoform 2)	Acetylation	-	25.31	-
2 (in isoform 2)	Phosphorylation	-	25.31	22673903
27	Acetylation	APAPAPAKPKEEKID CCCCCCCCCCHHHCC	56.41	22902405
36	Phosphorylation	KEEKIDLSAIKIEFS CHHHCCHHHEECEEC	24.97	22673903
39	Acetylation	KIDLSAIKIEFSKEQ HCCHHHEECEECHHH	35.58	22902405
44	Acetylation	AIKIEFSKEQQEEFK HEECEECHHHHHHHH	65.93	26302492
51	Acetylation	KEQQEEFKEAFLLFD HHHHHHHHHHHHHHC	51.95	22902405
64	Acetylation	FDRTGECKITLSQVG HCCCCCCEEEHHHHH	34.13	22902405
66	Phosphorylation	RTGECKITLSQVGDV CCCCCEEEHHHHHHH	13.07	22673903
68	Phosphorylation	GECKITLSQVGDVLR CCCEEEHHHHHHHHH	17.73	22673903
82	Phosphorylation	RALGTNPTNAEVKKV HHHCCCCCCHHHHHH	49.48	22673903
87	Acetylation	NPTNAEVKKVLGNPS CCCCHHHHHHHCCCC	28.77	22902405
94	Phosphorylation	KKVLGNPSNEEMNAK HHHHCCCCCHHHHHH	61.96	22673903
101	Acetylation	SNEEMNAKKIEFEQF CCHHHHHHHHCHHHH	49.64	22902405
102	Acetylation	NEEMNAKKIEFEQFL CHHHHHHHHCHHHHH	45.09	22902405
119	Acetylation	MQAISNNKDQGGYED HHHHHCCCCCCCCHH	56.53	22902405
136	Acetylation	EGLRVFDKEGNGTVM HEEEEEEECCCCEEE	56.93	22902405
141	Phosphorylation	FDKEGNGTVMGAELR EEECCCCEEEHHHHH	16.00	22673903
157	Ubiquitination	VLATLGEKMKEEEVE HHHHHHHHHCHHHHH	54.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYL1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYL1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MYL1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.