MUC18_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUC18_RAT
• UniProt AC: Q9EPF2
• Protein Name: Cell surface glycoprotein MUC18
• Gene Name: Mcam
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 648
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Perikaryon . Detected at the surface of the cell body of motor neurons.
• Protein Description: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity)..
• Protein Sequence: MGLPRLVCAFLFAACCCCRSATGVPGEEKQPTPTPDPVEVEVGNTALLKCGPAHPSGNFSQVEWFLIHKERQIPIFRVHQGKGQSEPGEYEHRLSLHGPGATLALSQVTPHDDRMFLCKSKQPRPQDHYVQLQVYKAPEEPTIQANVLGIHVDIQELKEVATCVGRNGYPIPQVIWYKNGRPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNRMKESKEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRCLTDGNPQPHFTINKKNPSTEEMEEESTDENGLLSLEPAQKHHSGVYQCQSLDLETTVMLSSDPLELLVNYVSDVQVDPTAPEVQEGDSLTLTCKAESNQDLEFEWLRDKTGQLLGKGPILQLNNVKREAGGRYLCVASVPSVPGLNRTRRVSVGIFGSPWMAAKERKVWAQENAMLNLSCEASGHPQPTISWNINGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTVIILKLVTLTTLTPDSSQTTGLSTPTVSPHSRANSTSTEKKLPQQESKGVVIVAVIVCTLVLAVLGATLYYFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	N-linked_Glycosylation	GPAHPSGNFSQVEWF CCCCCCCCHHHEEEE	37.42	-
85	Phosphorylation	VHQGKGQSEPGEYEH EECCCCCCCCCCCCE	55.19	17564427
95	Phosphorylation	GEYEHRLSLHGPGAT CCCCEEEEECCCCCE	20.48	-
426	Phosphorylation	LNRTRRVSVGIFGSP CCCCCEEEEEECCCH	16.89	17564427
510	N-linked_Glycosylation	ASNSLGSNTTVIILK CCCCCCCCCEEEEEE	37.66	-
523	Phosphorylation	LKLVTLTTLTPDSSQ EEEEEECEECCCCCC	31.57	-
531	Phosphorylation	LTPDSSQTTGLSTPT ECCCCCCCCCCCCCC	25.44	-
532	Phosphorylation	TPDSSQTTGLSTPTV CCCCCCCCCCCCCCC	28.61	-
535	Phosphorylation	SSQTTGLSTPTVSPH CCCCCCCCCCCCCCC	33.41	-
536	Phosphorylation	SQTTGLSTPTVSPHS CCCCCCCCCCCCCCC	28.20	-
543	Phosphorylation	TPTVSPHSRANSTST CCCCCCCCCCCCCCC	36.15	-
549	Phosphorylation	HSRANSTSTEKKLPQ CCCCCCCCCCCCCCH	34.10	-
550	Phosphorylation	SRANSTSTEKKLPQQ CCCCCCCCCCCCCHH	52.49	-
607	Acetylation	ITLPPTRKSEFVVEV EECCCCCCCCEEEEE	57.74	22902405
607	Ubiquitination	ITLPPTRKSEFVVEV EECCCCCCCCEEEEE	57.74	-
608	Phosphorylation	TLPPTRKSEFVVEVK ECCCCCCCCEEEEEC	32.73	22673903
616	Phosphorylation	EFVVEVKSDKLPEEM CEEEEECCCCCCHHH	45.19	-
618	Ubiquitination	VVEVKSDKLPEEMAL EEEECCCCCCHHHHH	73.38	-
643	Phosphorylation	PGDQGEKYIDLRH-- CCCCCCCEEECCC--	8.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
85	S	Phosphorylation	Kinase	PKACA	P00517	PSP
95	S	Phosphorylation	Kinase	PKACA	P00517	PSP
426	S	Phosphorylation	Kinase	PKACA	P00517	PSP
426	S	Phosphorylation	Kinase	PKG1	P00516	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUC18_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUC18_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MUC18_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.