dbPTM

MU174_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MU174_SCHPO
UniProt AC	O74434
Protein Name	Meiotically up-regulated gene 174 protein
Gene Name	mug174
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	626
Subcellular Localization	Cytoplasm .
Protein Description	Has a role in sporulation..
Protein Sequence	MLLKVSSCEPLVPIKQWIHTSQLDLSDSSSLVADLLYNIIKFNFSGLEDKRAIFTGYESIKRYTIGNEMFLQLAKDGFALPVSMSYGLFLEETDTLELRALPRSEGLHRGCEVLVLRLDSPNELKENIREWSSKFMNSKASQKQQMLSPETMQKVDLAGRASPRYQANDSWISKKRNAPLSSISQYANMPENYALNTKKSKISNENDTIFKANFQQNKYESLHAKQISASDLSLHQEFVSASIVQQPELNSLLTSQSKNSTPSESDSSSSESSSSVSDSSDLSSTSDSSSGDESSDTARQSSSDTISSNNVSVSVSLNTANEFSFPQGTFKAENEAVESEVAPSSSTPPTVEEISYLHYDEPSQYYFSSPSKLSSETTKVHRGCENTEKPSEEGKNFTTPLSDSVESENTWSNTLRSSVEDDNTGVSDDNKKSKLNAEFDGHVNNISVRPPGSGSSATKARNLRRKKARILKRLMQESNDTFSANESTVVANVPDSYLTKNDEEDSASLASLKVAPKYVSHPVSLSSNSFHTEFPIGSLMRFTVMDLNPVTCTPEISEKTGRVVDCSEEKVKIQLDLGDRLDLKFDVNGEVIRNRYGTTPDEELIEGIATYEWSSLSNVHKLELTN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
148	Phosphorylation	SQKQQMLSPETMQKV HHHHHCCCHHHHHHH	18.49	28889911
151	Phosphorylation	QQMLSPETMQKVDLA HHCCCHHHHHHHCCC	28.43	29996109
162	Phosphorylation	VDLAGRASPRYQAND HCCCCCCCCCCCCCC	14.46	28889911
165	Phosphorylation	AGRASPRYQANDSWI CCCCCCCCCCCCCCH	18.50	21712547
170	Phosphorylation	PRYQANDSWISKKRN CCCCCCCCCHHHCCC	26.56	21712547
424	Phosphorylation	SSVEDDNTGVSDDNK HHHCCCCCCCCCCCH	46.05	29996109
427	Phosphorylation	EDDNTGVSDDNKKSK CCCCCCCCCCCHHHH	40.36	29996109
453	Phosphorylation	ISVRPPGSGSSATKA EEECCCCCCCHHHHH	41.07	21712547
455	Phosphorylation	VRPPGSGSSATKARN ECCCCCCCHHHHHHH	20.63	21712547
456	Phosphorylation	RPPGSGSSATKARNL CCCCCCCHHHHHHHH	43.41	21712547
506	Phosphorylation	TKNDEEDSASLASLK CCCCHHCCCHHHHCE	24.04	25720772
508	Phosphorylation	NDEEDSASLASLKVA CCHHCCCHHHHCEEC	28.55	28889911
511	Phosphorylation	EDSASLASLKVAPKY HCCCHHHHCEECCCE	33.73	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MU174_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MU174_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MU174_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MU174_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MU174_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-162, ANDMASS SPECTROMETRY.	18257517 [Abstract]