MTL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTL5_HUMAN
• UniProt AC: Q9Y4I5
• Protein Name: Tesmin {ECO:0000303|PubMed:10191092}
• Gene Name: TESMIN {ECO:0000312|HGNC:HGNC:7446}
• Organism: Homo sapiens (Human).
• Sequence Length: 508
• Subcellular Localization: Cytoplasm . Nucleus . Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc.
• Protein Description: May have a role in spermatogenesis..
• Protein Sequence: MEEGPLPGGLPSPEDAMVTELLSPEGPFASENIGLKAPVKYEEDEFHVFKEAYLGPADPKEPVLHAFNPALGADCKGQVKAKLAGGDSDGGELLGEYPGIPELSALEDVALLQAPQPPACNVHFLSSLLPAHRSPAVLPLGAWVLEGASHPGVRMIPVEIKEAGGTTTSNNPEEATLQNLLAQESCCKFPSSQELEDASCCSLKKDSNPMVICQLKGGTQMLCIDNSRTRELKALHLVPQYQDQNNYLQSDVPKPMTALVGRFLPASTKLNLITQQLEGALPSVVNGSAFPSGSTLPGPPKITLAGYCDCFASGDFCNNCNCNNCCNNLHHDIERFKAIKACLGRNPEAFQPKIGKGQLGNVKPQHNKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYEESPERKTLMSMPNYMQTGGLEGSHYLPPTKFSGLPRFSHDRRPSSCISWEVVEATCACLLAQGEEAEKEHCSKCLAEQMILEEFGRCLSQILHTEFKSKGLKME

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PLPGGLPSPEDAMVT CCCCCCCCHHHHHHH	46.06	28348404
19	Phosphorylation	SPEDAMVTELLSPEG CHHHHHHHHHCCCCC	14.08	28348404
23	Phosphorylation	AMVTELLSPEGPFAS HHHHHHCCCCCCCCC	33.26	28348404
40	Acetylation	IGLKAPVKYEEDEFH CCCCCCCCCCCCCEE	45.98	19608861
134	Phosphorylation	SLLPAHRSPAVLPLG HCCCCCCCCCEEECC	13.82	21712546
166	Phosphorylation	EIKEAGGTTTSNNPE EEEECCCCCCCCCHH	26.44	19690332
167	Phosphorylation	IKEAGGTTTSNNPEE EEECCCCCCCCCHHH	31.34	19690332
185	Phosphorylation	QNLLAQESCCKFPSS HHHHHHHHHCCCCCC	16.85	22817900
283	Phosphorylation	QLEGALPSVVNGSAF HHHCCCCCCCCCCCC	39.28	28387310
292	Phosphorylation	VNGSAFPSGSTLPGP CCCCCCCCCCCCCCC	38.63	28387310
340	Ubiquitination	IERFKAIKACLGRNP HHHHHHHHHHHCCCH	37.60	29967540
381	Phosphorylation	RSGCLKNYCECYEAQ CCCCHHHHHHHHHHH	6.50	22210691
385	Phosphorylation	LKNYCECYEAQIMCS HHHHHHHHHHHHHHH	7.63	22210691
403	Phosphorylation	KCIGCKNYEESPERK HHHCCCCCCCCCCHH	13.43	22210691
406	Phosphorylation	GCKNYEESPERKTLM CCCCCCCCCCHHHHH	21.81	22210691
414	Phosphorylation	PERKTLMSMPNYMQT CCHHHHHCCCCHHHC	33.91	28985074
418	Phosphorylation	TLMSMPNYMQTGGLE HHHCCCCHHHCCCCC	5.68	-
433	Phosphorylation	GSHYLPPTKFSGLPR CCCCCCCCCCCCCCC	42.66	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTL5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTL5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTL5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MTL5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185, AND MASSSPECTROMETRY.
PubMed: 19690332