dbPTM

MTHR_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTHR_CAEEL
UniProt AC	Q17693
Protein Name	Probable methylenetetrahydrofolate reductase
Gene Name	mthf-1 {ECO:0000312\|WormBase:C06A8.1a}
Organism	Caenorhabditis elegans.
Sequence Length	663
Subcellular Localization
Protein Description
Protein Sequence	MTNTGETKVIESHGTIKKIDSLSTMPYCGVETDENAVVEEKITLESGKSWSPKHYELLHERIERLIDEKQQFFSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANVDKVTSSSSIAASMLDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRGDLPPGTELEDTHQFRALDMIRWIREEYGNYFSIGCAGYPLGHPQAPSYKADLMYLKAKCDAGANFVITQLFFEAETFEKFVRDCREIGITQPIIPGIMPIMGYESIKRIAKLSQLEIPQHILDDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLYTMNREGSIREILKSLGLWKLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTRDWDQFPNGRWGNSSSPAFGDVSSYYLSNLTTVRNADDRLAMFGANIESFEDVKRVFINYITQAPNADGVKVTVLPWTEAETGVQPETSLISEQLVWCNENGILTVNSQPSVNGAPSTDPLVGWGKPGGYCYQKAYLECFMTAELSDKLIQIIEREFPVRVNYHAINKDSTFDKTNSEETTPIAVTWGVFPGSEIAQPTVVDPLSFRAWRDEAYQMWMAQWGDFYPKESKSYGVIKAVHDEFRLVTLVDNDFQKPSVLFDVLQKALDELKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GTIKKIDSLSTMPYC CCEEECCCCCCCCCC	27.91	28854356
23	Phosphorylation	IKKIDSLSTMPYCGV EEECCCCCCCCCCCC	26.98	30078680
24	Phosphorylation	KKIDSLSTMPYCGVE EECCCCCCCCCCCCC	27.71	30078680
27	Phosphorylation	DSLSTMPYCGVETDE CCCCCCCCCCCCCCC	7.33	19530675
380	Phosphorylation	LESVRPIYWSFRPRS HHHCCCEEEECCCCC	9.55	27067626

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTHR_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTHR_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTHR_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MTHR_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTHR_CAEEL

Related Literatures of Post-Translational Modification