MTG16_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTG16_MOUSE
• UniProt AC: O54972
• Protein Name: Protein CBFA2T3
• Gene Name: Cbfa2t3
• Organism: Mus musculus (Mouse).
• Sequence Length: 620
• Subcellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm . Golgi apparatus membrane.
• Protein Description: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. [PubMed: 16407974 Plays a role in granulocyte differentiation]
• Protein Sequence: MSQASTTTLESGALLSGPRGLQYGSPAHRKEKAAAMPDSPAEVKTQPRSTPPSMPPPPPTSSQGATRPPSFTPHTHGEDGPATSLPHGRFHGCLKWSMVCLLMNGSSHSPTAIHGAPSTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASATSPVDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPDHLSKRSCTLSPAQRCSPSNGLPHPTPPPPPHYRLEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGSRQEEVIDHRLTEREWAEEWKHLNSLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWIRCYSDSEEGKKGPTPISARSLNSCSGPEGSQLDVHRDFTPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHKDWEKHHHVCGQSLQGPAAAVADPLPGQPDATASPSEAGSAGPSRPCSPGPPGPLDAAVPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	11.09	27841257
39	Phosphorylation	KAAAMPDSPAEVKTQ HHHCCCCCCHHHCCC	21.82	26745281
248	Phosphorylation	EQLLLDASATSPVDS HHHHHHHCCCCCCCH	31.57	26745281
250	Phosphorylation	LLLDASATSPVDSSE HHHHHCCCCCCCHHH	30.94	26745281
251	Phosphorylation	LLDASATSPVDSSEL HHHHCCCCCCCHHHH	23.73	26745281
255	Phosphorylation	SATSPVDSSELLLEV CCCCCCCHHHHEEEE	26.41	26745281
256	Phosphorylation	ATSPVDSSELLLEVN CCCCCCHHHHEEEEC	28.00	26745281
297	Phosphorylation	SKRSCTLSPAQRCSP CCCCCCCCHHHHCCC	10.47	26745281
303	Phosphorylation	LSPAQRCSPSNGLPH CCHHHHCCCCCCCCC	33.29	21082442
312	Phosphorylation	SNGLPHPTPPPPPHY CCCCCCCCCCCCCCC	45.45	21082442
456	Phosphorylation	DFTPRTLSGYMPEEI CCCCCHHCCCCCHHH	27.54	27600695
603	Phosphorylation	EAGSAGPSRPCSPGP HCCCCCCCCCCCCCC	48.19	-
607	Phosphorylation	AGPSRPCSPGPPGPL CCCCCCCCCCCCCCC	35.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTG16_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTG16_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTG16_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MTG16_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.