MTA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTA1_RAT
• UniProt AC: Q62599
• Protein Name: Metastasis-associated protein MTA1
• Gene Name: Mta1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 703
• Subcellular Localization: Isoform 1: Nucleus. Nucleus envelope . Cytoplasm. Cytoplasm, cytoskeleton. Associated with microtubules. Localization at the nuclear envelope is TPR-dependent (By similarity)..; Isoform 2: Rough endoplasmic reticulum. Golgi apparatus. Cytoplasmic ves
• Protein Description: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). Isoform 2 may be involved in the sorting of amylase during zymogen granule formation in the pancreas. With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity)..
• Protein Sequence: MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNSVKASVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	FYRRRDISSSLIALA EEECCCCCHHHHHHH	20.40	28432305
53	Phosphorylation	YRRRDISSSLIALAD EECCCCCHHHHHHHH	29.51	28432305
54	Phosphorylation	RRRDISSSLIALADK ECCCCCHHHHHHHHH	19.60	27097102
380	Phosphorylation	KASVVNGTGTPGQSP EEEEECCCCCCCCCC	32.45	23984901
382	Phosphorylation	SVVNGTGTPGQSPGA EEECCCCCCCCCCCC	24.88	28689409
386	Phosphorylation	GTGTPGQSPGAGRAC CCCCCCCCCCCCCCC	31.08	27097102
449	Phosphorylation	GPNRNNMSPHGIPAR CCCCCCCCCCCCCCC	18.83	23712012
520	Phosphorylation	TARLPEASQSPLVLK HHCCCHHHCCCCHHH	29.54	27097102
522	Phosphorylation	RLPEASQSPLVLKQV CCCHHHCCCCHHHHH	20.08	27097102
561	Phosphorylation	KSSSSVLSSLTPAKS CCCHHHHHHCCCCCC	22.58	28432305
562	Phosphorylation	SSSSVLSSLTPAKSA CCHHHHHHCCCCCCC	31.91	28432305
564	Phosphorylation	SSVLSSLTPAKSAPV HHHHHHCCCCCCCCC	24.13	27097102
576	Phosphorylation	APVINNGSPTILGKR CCCCCCCCCCCCCCC	22.46	23712012
578	Phosphorylation	VINNGSPTILGKRSY CCCCCCCCCCCCCCH	30.45	27097102
583	Methylation	SPTILGKRSYEQHNG CCCCCCCCCHHCCCC	42.55	26494469
614	Acetylation	RNLLLNGKSYPTKVR CCEEECCCCCCCEEE	45.82	-
624	Methylation	PTKVRLIRGGSLPPV CCEEEEEECCCCCCC	48.27	26494463
627	Phosphorylation	VRLIRGGSLPPVKRR EEEEECCCCCCCCCC	40.29	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTA1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MTA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.