MT1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MT1A_HUMAN
• UniProt AC: P04731
• Protein Name: Metallothionein-1A
• Gene Name: MT1A
• Organism: Homo sapiens (Human).
• Sequence Length: 61
• Protein Description: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids..
• Protein Sequence: MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPNCSCA -------CCCCCCCC	20.42	-
20	Ubiquitination	CTCTGSCKCKECKCT CEECCCCCCCCCCCC	50.46	23503661
22	Ubiquitination	CTGSCKCKECKCTSC ECCCCCCCCCCCCCC	52.20	23503661
25	Ubiquitination	SCKCKECKCTSCKKS CCCCCCCCCCCCCCC	41.46	27667366
28	Phosphorylation	CKECKCTSCKKSCCS CCCCCCCCCCCCCCC	33.15	28258704
30	Ubiquitination	ECKCTSCKKSCCSCC CCCCCCCCCCCCCCC	47.70	23503661
31	Ubiquitination	CKCTSCKKSCCSCCP CCCCCCCCCCCCCCC	53.72	23503661
32	Phosphorylation	KCTSCKKSCCSCCPM CCCCCCCCCCCCCCC	13.07	28258704
43	Ubiquitination	CCPMSCAKCAQGCIC CCCCHHHHHHCCCEE	34.14	23503661
51	Ubiquitination	CAQGCICKGASEKCS HHCCCEECCCCCCCC	37.28	23000965
51	Acetylation	CAQGCICKGASEKCS HHCCCEECCCCCCCC	37.28	26210075
56	Ubiquitination	ICKGASEKCSCCA-- EECCCCCCCCCCC--	29.02	23000965
56	Acetylation	ICKGASEKCSCCA-- EECCCCCCCCCCC--	29.02	26210075
58	Phosphorylation	KGASEKCSCCA---- CCCCCCCCCCC----	24.25	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MT1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MT1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MT1A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MT1A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.