MSPD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSPD1_HUMAN
• UniProt AC: Q9UJG1
• Protein Name: Motile sperm domain-containing protein 1
• Gene Name: MOSPD1
• Organism: Homo sapiens (Human).
• Sequence Length: 213
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation..
• Protein Sequence: MHQQKRQPELVEGNLPVFVFPTELIFYADDQSTHKQVLTLYNPYEFALKFKVLCTTPNKYVVVDAAGAVKPQCCVDIVIRHRDVRSCHYGVIDKFRLQVSEQSQRKALGRKEVVATLLPSAKEQQKEEEEKRLKEHLTESLFFEQSFQPENRAVSSGPSLLTVFLGVVCIAALMLPTLGDVESLVPLYLHLSVNQKLVAAYILGLITMAILRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	YEFALKFKVLCTTPN HHHHHEEEEEECCCC	32.48	29967540
51	Malonylation	YEFALKFKVLCTTPN HHHHHEEEEEECCCC	32.48	26320211
56	Phosphorylation	KFKVLCTTPNKYVVV EEEEEECCCCCEEEE	24.70	25159151
103	Phosphorylation	RLQVSEQSQRKALGR HHCCCHHHHHHHCCC	28.09	-
111	Ubiquitination	QRKALGRKEVVATLL HHHHCCCHHHHHHHC	53.73	29967540
116	Phosphorylation	GRKEVVATLLPSAKE CCHHHHHHHCHHHHH	19.74	22210691
120	Phosphorylation	VVATLLPSAKEQQKE HHHHHCHHHHHHHHH	52.52	24719451
122	Ubiquitination	ATLLPSAKEQQKEEE HHHCHHHHHHHHHHH	61.46	32015554
126	Ubiquitination	PSAKEQQKEEEEKRL HHHHHHHHHHHHHHH	67.78	-
131	Ubiquitination	QQKEEEEKRLKEHLT HHHHHHHHHHHHHHH	67.33	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSPD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSPD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSPD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MSPD1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.