dbPTM

MSH7_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSH7_ARATH
UniProt AC	Q9SMV7
Protein Name	DNA mismatch repair protein MSH7
Gene Name	MSH7
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1109
Subcellular Localization	Nucleus .
Protein Description	Component of the post-replicative DNA mismatch repair system (MMR). Forms the heterodimer MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS gamma recognizes specifically the T/G single base mismatch, but not trinucleotide insertion-deletion loops (IDL)..
Protein Sequence	MQRQRSILSFFQKPTAATTKGLVSGDAASGGGGSGGPRFNVKEGDAKGDASVRFAVSKSVDEVRGTDTPPEKVPRRVLPSGFKPAESAGDASSLFSNIMHKFVKVDDRDCSGERSREDVVPLNDSSLCMKANDVIPQFRSNNGKTQERNHAFSFSGRAELRSVEDIGVDGDVPGPETPGMRPRASRLKRVLEDEMTFKEDKVPVLDSNKRLKMLQDPVCGEKKEVNEGTKFEWLESSRIRDANRRRPDDPLYDRKTLHIPPDVFKKMSASQKQYWSVKSEYMDIVLFFKVGKFYELYELDAELGHKELDWKMTMSGVGKCRQVGISESGIDEAVQKLLARGYKVGRIEQLETSDQAKARGANTIIPRKLVQVLTPSTASEGNIGPDAVHLLAIKEIKMELQKCSTVYGFAFVDCAALRFWVGSISDDASCAALGALLMQVSPKEVLYDSKGLSREAQKALRKYTLTGSTAVQLAPVPQVMGDTDAAGVRNIIESNGYFKGSSESWNCAVDGLNECDVALSALGELINHLSRLKLEDVLKHGDIFPYQVYRGCLRIDGQTMVNLEIFNNSCDGGPSGTLYKYLDNCVSPTGKRLLRNWICHPLKDVESINKRLDVVEEFTANSESMQITGQYLHKLPDLERLLGRIKSSVRSSASVLPALLGKKVLKQRVKAFGQIVKGFRSGIDLLLALQKESNMMSLLYKLCKLPILVGKSGLELFLSQFEAAIDSDFPNYQNQDVTDENAETLTILIELFIERATQWSEVIHTISCLDVLRSFAIAASLSAGSMARPVIFPESEATDQNQKTKGPILKIQGLWHPFAVAADGQLPVPNDILLGEARRSSGSIHPRSLLLTGPNMGGKSTLLRATCLAVIFAQLGCYVPCESCEISLVDTIFTRLGASDRIMTGESTFLVECTETASVLQNATQDSLVILDELGRGTSTFDGYAIAYSVFRHLVEKVQCRMLFATHYHPLTKEFASHPRVTSKHMACAFKSRSDYQPRGCDQDLVFLYRLTEGACPESYGLQVALMAGIPNQVVETASGAAQAMKRSIGENFKSSELRSEFSSLHEDWLKSLVGISRVAHNNAPIGEDDYDTLFCLWHEIKSSYCVPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	KVDDRDCSGERSRED CCCCCCCCCCCCCCC	48.23	24894044
798	Phosphorylation	IFPESEATDQNQKTK ECCCHHCCCCCCCCC	33.78	26811356
904	Phosphorylation	GASDRIMTGESTFLV CCCCCEECCCCEEEE	35.11	23776212
907	Phosphorylation	DRIMTGESTFLVECT CCEECCCCEEEEEEC	26.29	23776212
908	Phosphorylation	RIMTGESTFLVECTE CEECCCCEEEEEECC	19.38	23776212
914	Phosphorylation	STFLVECTETASVLQ CEEEEEECCHHHHHC	23.90	23776212
916	Phosphorylation	FLVECTETASVLQNA EEEEECCHHHHHCCC	13.18	23776212
918	Phosphorylation	VECTETASVLQNATQ EEECCHHHHHCCCCC	30.68	23776212
924	Phosphorylation	ASVLQNATQDSLVIL HHHHCCCCCCCEEEE	40.22	23776212
927	Phosphorylation	LQNATQDSLVILDEL HCCCCCCCEEEEECC	18.08	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSH7_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSH7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSH7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MSH7_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSH7_ARATH

Related Literatures of Post-Translational Modification