dbPTM

MSH5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSH5_MOUSE
UniProt AC	Q9QUM7
Protein Name	MutS protein homolog 5
Gene Name	Msh5
Organism	Mus musculus (Mouse).
Sequence Length	833
Subcellular Localization
Protein Description	Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity)..
Protein Sequence	MAFRATPGRTPPGPGPRSGIPSASFPSPQPPMAGPGGIEEEDEEEPAEIHLCVLWSSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDEAMTRFLGKLASEEHREPKGPEIILLPSVDFGPEISKQRLLSGNYSFISDSMTATEKILFLSSIIPFDCVLTVRALGGLLKFLSRRRIGVELEDYDVGVPILGFKKFVLTHLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGQKLLRLWFTRPTRELRELNSRLDVIQFFLMPQNLDMAQMLHRLLSHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFQDIAQEFSDDLHHIASLIGKVVDFEESLAENRFTVLPNIDPDIDAKKRRLIGLPSFLTEVAQKELENLDSRIPSCSVIYIPLIGFLLSIPRLPFMVEASDFEIEGLDFMFLSEDKLHYRSARTKELDTLLGDLHCEIRDQETLLMYQLQCQVLARASVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCIHGVRIRNGRHPLMELCARTFVPNSTDCGGDQGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGTNSVDGLALLAAVLRHWLALGPSCPHVFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGEDLVFFYQLCQGVASASHASHTAAQAGLPDPLIARGKEVSDLIRSGKPIKATNELLRRNQMENCQALVDKFLKLDLEDPTLDLDIFISQEVLPAAPTIL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	LDEINPQSVVTSAKQ HHHCCCHHHHCCHHH	21.58	25338131
101	Phosphorylation	INPQSVVTSAKQDEA CCCHHHHCCHHHHHH	22.32	25338131
118	Phosphorylation	RFLGKLASEEHREPK HHHHHHHCHHHCCCC	54.69	24719451
151	Phosphorylation	QRLLSGNYSFISDSM HHHHCCCCCCCCCCC	14.42	21659604
152	Phosphorylation	RLLSGNYSFISDSMT HHHCCCCCCCCCCCC	21.80	21659604
161	Phosphorylation	ISDSMTATEKILFLS CCCCCCHHHHHHHHH	28.75	21659604
169	Phosphorylation	EKILFLSSIIPFDCV HHHHHHHCCCCCCHH	27.04	-
516	Phosphorylation	CQVLARASVLTRVLD HHHHHHHHHHHHHHH	16.47	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSH5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSH5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSH5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MSH5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSH5_MOUSE

Related Literatures of Post-Translational Modification