dbPTM

MSH3_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSH3_ARATH
UniProt AC	O65607
Protein Name	DNA mismatch repair protein MSH3
Gene Name	MSH3
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1081
Subcellular Localization	Nucleus .
Protein Description	Component of the post-replicative DNA mismatch repair system (MMR). Forms the heterodimer MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS beta recognizes single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA..
Protein Sequence	MGKQKQQTISRFFAPKPKSPTHEPNPVAESSTPPPKISATVSFSPSKRKLLSDHLAAASPKKPKLSPHTQNPVPDPNLHQRFLQRFLEPSPEEYVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFGEDAEIAARVLGIYAHMDHNFMTASVPTFRLNFHVRRLVNAGYKIGVVKQTETAAIKSHGANRTGPFFRGLSALYTKATLEAAEDISGGCGGEEGFGSQSNFLVCVVDERVKSETLGCGIEMSFDVRVGVVGVEISTGEVVYEEFNDNFMRSGLEAVILSLSPAELLLGQPLSQQTEKFLVAHAGPTSNVRVERASLDCFSNGNAVDEVISLCEKISAGNLEDDKEMKLEAAEKGMSCLTVHTIMNMPHLTVQALALTFCHLKQFGFERILYQGASFRSLSSNTEMTLSANTLQQLEVVKNNSDGSESGSLFHNMNHTLTVYGSRLLRHWVTHPLCDRNLISARLDAVSEISACMGSHSSSQLSSELVEEGSERAIVSPEFYLVLSSVLTAMSRSSDIQRGITRIFHRTAKATEFIAVMEAILLAGKQIQRLGIKQDSEMRSMQSATVRSTLLRKLISVISSPVVVDNAGKLLSALNKEAAVRGDLLDILITSSDQFPELAEARQAVLVIREKLDSSIASFRKKLAIRNLEFLQVSGITHLIELPVDSKVPMNWVKVNSTKKTIRYHPPEIVAGLDELALATEHLAIVNRASWDSFLKSFSRYYTDFKAAVQALAALDCLHSLSTLSRNKNYVRPEFVDDCEPVEINIQSGRHPVLETILQDNFVPNDTILHAEGEYCQIITGPNMGGKSCYIRQVALISIMAQVGSFVPASFAKLHVLDGVFTRMGASDSIQHGRSTFLEELSEASHIIRTCSSRSLVILDELGRGTSTHDGVAIAYATLQHLLAEKRCLVLFVTHYPEIAEISNGFPGSVGTYHVSYLTLQKDKGSYDHDDVTYLYKLVRGLCSRSFGFKVAQLAQIPPSCIRRAISMAAKLEAEVRARERNTRMGEPEGHEEPRGAEESISALGDLFADLKFALSEEDPWKAFEFLKHAWKIAGKIRLKPTCSF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	VLMVEVGYRYRFFGE EEEEEECCHHEECCC	15.06	24894044
1019	Phosphorylation	VRARERNTRMGEPEG HHHHHHCCCCCCCCC	28.40	19880383
1036	Phosphorylation	EPRGAEESISALGDL CCCCHHHHHHHHHHH	17.22	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSH3_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSH3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSH3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MSH3_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSH3_ARATH

Related Literatures of Post-Translational Modification