dbPTM

MSD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSD2_MOUSE
UniProt AC	Q6NZR2
Protein Name	Myb/SANT-like DNA-binding domain-containing protein 2
Gene Name	Msantd2
Organism	Mus musculus (Mouse).
Sequence Length	559
Subcellular Localization
Protein Description
Protein Sequence	MAAPCGSELPANSPLKIPKMEVLSPASPGDLSDGNPSLSDPSTPRGASPLGPGSAAGSGAAASGGLGLGLGGRGAASSSVSFSPGGGSGGAAAAAAAACRGMSWTPAETNALIAVWGNERLVEARYQQLEGAGTVFGSKAPGPAMYERVSRALAELGYERTPSQCRERIKTLRRCYSRVKEHGVGKRKSSYTFEQLEQVFGQGGWDAQPCQPVLINSSGLYQELESDGSTMEDYSQEDWGNHSQELHGYPTDQELDEMPVSKRTLKIKQESSEEAQKRDTMQNIVQILESVQLKWELFQSWTDFSRLHLSNKLAIFGIGYNTRWKEDIRYHYAEISSQVPLGKRLREYFNSEKPEGRIIMTRVQKMNWKNVYYKFLEITISEARCLELHMEIDWIPIAHSKPTGGNVVQYLLPGGIPKSPGLYAIGYEECIERPLSPDVERHALDPGKEGRVDLETLSAQASLQVEVEPTRIIYCYLGIAEVRTLQQCLFLHFQANAKTFSKEWVGINGFLSQNCIVDPGVSPKSIYIKFVEVERDFLSAGSLVECLEKAIGYPLKFNN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	GSELPANSPLKIPKM CCCCCCCCCCCCCCE	33.44	25263469
24	Phosphorylation	IPKMEVLSPASPGDL CCCEEEECCCCCCCC	24.48	25619855
27	Phosphorylation	MEVLSPASPGDLSDG EEEECCCCCCCCCCC	32.57	26824392
32	Phosphorylation	PASPGDLSDGNPSLS CCCCCCCCCCCCCCC	48.49	22942356
37	Phosphorylation	DLSDGNPSLSDPSTP CCCCCCCCCCCCCCC	44.50	25619855
39	Phosphorylation	SDGNPSLSDPSTPRG CCCCCCCCCCCCCCC	52.38	25619855
42	Phosphorylation	NPSLSDPSTPRGASP CCCCCCCCCCCCCCC	56.91	25619855
43	Phosphorylation	PSLSDPSTPRGASPL CCCCCCCCCCCCCCC	23.53	25619855
48	Phosphorylation	PSTPRGASPLGPGSA CCCCCCCCCCCCCCC	24.39	26824392
54	Phosphorylation	ASPLGPGSAAGSGAA CCCCCCCCCCCCCHH	20.34	25619855
58	Phosphorylation	GPGSAAGSGAAASGG CCCCCCCCCHHHCCC	22.11	25619855
63	Phosphorylation	AGSGAAASGGLGLGL CCCCHHHCCCCCCCC	28.77	25619855
77	Phosphorylation	LGGRGAASSSVSFSP CCCCCCCCCCEEECC	23.70	25619855
78	Phosphorylation	GGRGAASSSVSFSPG CCCCCCCCCEEECCC	29.99	25619855
79	Phosphorylation	GRGAASSSVSFSPGG CCCCCCCCEEECCCC	21.20	25619855
81	Phosphorylation	GAASSSVSFSPGGGS CCCCCCEEECCCCCH	23.19	25619855
83	Phosphorylation	ASSSVSFSPGGGSGG CCCCEEECCCCCHHH	18.35	25619855
88	Phosphorylation	SFSPGGGSGGAAAAA EECCCCCHHHHHHHH	37.01	25619855
271	Phosphorylation	TLKIKQESSEEAQKR CEEECHHCCHHHHHH	40.32	29514104
419	Phosphorylation	LPGGIPKSPGLYAIG ECCCCCCCCCEEEEC	20.88	25777480
423	Phosphorylation	IPKSPGLYAIGYEEC CCCCCCEEEECHHHH	11.33	25777480
427	Phosphorylation	PGLYAIGYEECIERP CCEEEECHHHHHCCC	11.48	22817900
436	Phosphorylation	ECIERPLSPDVERHA HHHCCCCCCCHHHHC	23.03	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSD2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSD2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MSD2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSD2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, AND MASSSPECTROMETRY.	17242355 [Abstract]