dbPTM

MRVI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MRVI1_HUMAN
UniProt AC	Q9Y6F6
Protein Name	Protein MRVI1
Gene Name	MRVI1
Organism	Homo sapiens (Human).
Sequence Length	904
Subcellular Localization	Cytoplasm, perinuclear region. Sarcoplasmic reticulum. Membrane Single-pass membrane protein .
Protein Description	Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation..
Protein Sequence	MGMDLTCPFGISPACGAQASWSIFGADAAEVPGTRGHSQQEAAMPHIPEDEEPPGEPQAAQSPAGQGPPAAGVSCSPTPTIVLTGDATSPEGETDKNLANRVHSPHKRLSHRHLKVSTASLTSVDPAGHIIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGDSPSAVSPNLSPSASPTSSRSNSLTVPTPPGLDVCSGPPSPLPGAPPQQKGDEADVSSPHPGEPNVPKGLADRKQNDQRKVSQGRLAPRPPPVEKSKEIAIEQKENFDPLQYPETTPKGLAPVTNSSGKMALNSPQPGPVESELGKQLLKTGWEGSPLPRSPTQDAAGVGPPASQGRGPAGEPMGPEAGSKAELPPTVSRPPLLRGLSWDSGPEEPGPRLQKVLAKLPLAEEEKRFAGKAGGKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGLKLPDLSEAAEQEKGLPSELSPAIEEEESKSGLDVMPNISDVLLRKLRVHRSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTLGKNMPRRRVSVAVVPKFNALNLPGQTPSSSSIPSLPALSESPNGKGSLPVTSALPALLESGKTNGDPDCEASAPALTLSCLEELSQETKARMEEEAYSKGFQEGLKKTKELQDLKEEEEEQKSESPEEPEEVEETEEEEKGPRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLTVVLGLYNSYNSCAEQADGPLGRSTCSAAQRDSWWSSGLQHEQPTEQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
481	Phosphorylation	KGLPSELSPAIEEEE CCCCCCCCHHHHHHH	28.45	20058876
708	Phosphorylation	LPGQTPSSSSIPSLP CCCCCCCCCCCCCCC	5.58	11309393

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
670	S	Phosphorylation	Kinase	PRKG1	P00516	GPS
670	S	Phosphorylation	Kinase	PRKG2	Q61410	GPS
689	S	Phosphorylation	Kinase	PKG1	P00516	PSP
689	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
689	S	Phosphorylation	Kinase	PKG2	Q61410	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MRVI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MRVI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITPR1_HUMAN	ITPR1	physical	10724174
KGP1_HUMAN	PRKG1	physical	10724174
KGP1_HUMAN	PRKG1	physical	11309393

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MRVI1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"IRAG mediates NO/cGMP-dependent inhibition of platelet aggregationand thrombus formation."; Antl M., von Bruehl M.-L., Eiglsperger C., Werner M., Konrad I.,Kocher T., Wilm M., Hofmann F., Massberg S., Schlossmann J.; Blood 109:552-559(2007). Cited for: INTERACTION WITH PRKG1 AND ITPR1, AND PHOSPHORYLATION AT SER-367;SER-657 AND SER-670.	16990611 [Abstract]