dbPTM

MRS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MRS2_MOUSE
UniProt AC	Q5NCE8
Protein Name	Magnesium transporter MRS2 homolog, mitochondrial
Gene Name	Mrs2
Organism	Mus musculus (Mouse).
Sequence Length	434
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits..
Protein Sequence	MECLRCLPGLLPRAAQPRRALWTAVARLSLAACGGRATPLRSRSPKASSTARAAGDVLRFRTSDASQATLASVAQVFAVTKFDKEGNVTSFERKKTELYHELALQARDLRFQHVMSITTRNNRIIMRMEYLKAVITPECLLILDYRNLNLEHWLFRELPSQLAGEGQLVTYPLPFEFRAIEALLQYWISTLRGRLSVLQPLILETLDALVDPKHSSVDRSKLHVLLQNGKSLSELETDIKIFKESILELLDEEEMLEELCLTKWSDPHVFEKSSTGIDHAEEMELLLENYYRLAEDLSNEARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRVFWLVTGIMFMGSGLIWRRLLSFLGRQLEAPVPPVMTSLPKKTLLANRRMDVKNSLRPEGLGASRTILASR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	RSRSPKASSTARAAG HHCCCCCCHHHHHHC	34.06	28059163
62	Phosphorylation	GDVLRFRTSDASQAT CCEEEEECCCHHHHH	28.39	21454597
66	Phosphorylation	RFRTSDASQATLASV EEECCCHHHHHHHHH	25.91	21454597
80	Phosphorylation	VAQVFAVTKFDKEGN HHHHHHEEEECCCCC	23.67	21454597
81	Acetylation	AQVFAVTKFDKEGNV HHHHHEEEECCCCCC	44.99	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MRS2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MRS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MRS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MRS2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MRS2_MOUSE

Related Literatures of Post-Translational Modification