MRP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRP9_HUMAN
• UniProt AC: Q96J65
• Protein Name: Multidrug resistance-associated protein 9
• Gene Name: ABCC12
• Organism: Homo sapiens (Human).
• Sequence Length: 1359
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Probable transporter..
• Protein Sequence: MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVGEGPYLISDLDQ -CCCCCCCCCCCHHH	27.76	141923
20	Phosphorylation	DQRGRRRSFAERYDP HHHCCHHHHHHHHCC	27.31	46156721
121	Phosphorylation	VVWKFQRTRVLMDIV HHHHHHHHHHHHHHH	17.85	68709173
290	Phosphorylation	LNSAFRRSAILVTDK HHHHHHHHEEEEECC	18.53	46156727
313	Ubiquitination	LTCIRLIKMYAWEKS HHHHHHHHHHHHHHH	30.37	-
324	Phosphorylation	WEKSFTNTIQDIRRR HHHHHHHHHHHHHHH	19.56	50558625
405	N-linked_Glycosylation	IKAMAEANVSLRRMK HHHHHHCCCCHHHHH	18.53	UniProtKB CARBOHYD
407	Phosphorylation	AMAEANVSLRRMKKI HHHHCCCCHHHHHHH	18.90	81114625
438	N-linked_Glycosylation	DTVLLLANATLTWEH CCEEEEEECEEECCH	33.17	UniProtKB CARBOHYD
472	Phosphorylation	KKQRSEAYSERSPPA HHHHHHHHHCCCCCC	13.65	30576142
483	Phosphorylation	SPPAKGATGPEEQSD CCCCCCCCCCHHHCH	63.04	22210691
489	Phosphorylation	ATGPEEQSDSLKSVL CCCCHHHCHHHHHHH	32.23	22210691
491	Phosphorylation	GPEEQSDSLKSVLHS CCHHHCHHHHHHHHH	42.83	30576142
498	Phosphorylation	SLKSVLHSISFVVRK HHHHHHHHHHHHEEC	18.77	22210691
540	N-linked_Glycosylation	QKGVVAVNGTLAYVS CCCEEEECCCEEEEE	28.17	UniProtKB CARBOHYD
542	Phosphorylation	GVVAVNGTLAYVSQQ CEEEECCCEEEEECC	11.74	46156733
895	Phosphorylation	VFDKILKSPMSFFDT HHHHHHCCCCCCCCC	23.53	68703685
898	Phosphorylation	KILKSPMSFFDTTPT HHHCCCCCCCCCCCC	26.58	68703691
905	Phosphorylation	SFFDTTPTGRLMNRF CCCCCCCCHHHHHHH	32.61	68711993
978	Ubiquitination	RGVQELKKVENVSRS HHHHHHHHHCCCCCC	68.36	25015289
981	N-linked_Glycosylation	QELKKVENVSRSPWF HHHHHHCCCCCCCCH	39.80	UniProtKB CARBOHYD
1093	Phosphorylation	SVELLREYISTCVPE CHHHHHHHHHHHCCC	8.17	6834565
1146	Phosphorylation	SLNLNIQSGQTVGIV EEEEEECCCCEEEEE	29.13	50558617
1158	Phosphorylation	GIVGRTGSGKSSLGM EEEECCCCCCHHHHH	42.29	-
1189	Phosphorylation	EVDICILSLEDLRTK EECEEEEEHHHHHHH	15.14	22167270
1291	Phosphorylation	TASMDSKTDTLVQNT HHCCCCCHHHHHHHH	37.86	28634298
1293	Phosphorylation	SMDSKTDTLVQNTIK CCCCCHHHHHHHHHH	33.78	28634298
1298	Phosphorylation	TDTLVQNTIKDAFKG HHHHHHHHHHHHHCC	16.59	28634298
1337	Acetylation	GKVIEFDKPEVLAEK CEEEEECCHHHHCCC	48.69	7927367
1344	Acetylation	KPEVLAEKPDSAFAM CHHHHCCCCCCHHHH	48.82	7927377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRP9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRP9_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MRP9_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.