MRP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRP2_RAT
• UniProt AC: Q63120
• Protein Name: Canalicular multispecific organic anion transporter 1
• Gene Name: Abcc2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1541
• Subcellular Localization: Apical cell membrane; Multi-pass membrane protein .
• Protein Description: Mediates hepatobiliary excretion of numerous organic anions..
• Protein Sequence: MDKFCNSTFWDLSLLESPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYSVYRSRTKRSSITKFYLAKQVFVVFLLILAAIDLSLALTEDTGQATVPPVRYTNPILYLCTWLLVLAVQHSRQWCVRKNSWFLSLFWILSVLCGVFQFQTLIRALLKDSKSNMAYSYLFFVSYGFQIVLLILTAFSGPSDSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQAFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICAILMFAVTLIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLERYLGGDDLDTSAIRRVSNFDKAVKFSEASFTWDPDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGLNNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPWVTDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLSNRGSFYLMAKEAGIENVNHTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	N-linked_Glycosylation	--MDKFCNSTFWDLS --CCCCCCCCCCCHH	47.41	-
279	Phosphorylation	HGLNKKQSQSQDVLV HCCCCCCCCCCCEEH	40.45	22673903
281	Phosphorylation	LNKKQSQSQDVLVLE CCCCCCCCCCEEHHH	33.33	29779826
627	Phosphorylation	TSAIRRVSNFDKAVK HHHHHHHCCHHHHCE	29.93	29779826
798	Acetylation	VGKHIFNKVVGPNGL HHHHHHHCCCCCCCC	27.78	22902405
862	Phosphorylation	WKTFMKHSGPEGEAT HHHHHHHCCCCCCEE	50.99	22673903
869	Phosphorylation	SGPEGEATVNNDSEA CCCCCCEEECCCCCC	21.33	29779826
874	Phosphorylation	EATVNNDSEAEDDDD CEEECCCCCCCCCCC	40.61	22673903
886	Phosphorylation	DDDGLIPTMEEIPED CCCCCCCCHHHCCHH	30.16	22673903
896	Phosphorylation	EIPEDAASLAMRREN HCCHHHHHHHHHHHH	20.55	22673903
904	Phosphorylation	LAMRRENSLRRTLSR HHHHHHHHHHHHHHH	20.64	29779826
922	Phosphorylation	SSSRRGKSLKNSLKI CCCCCCCHHHHHHHC	47.61	29779826
926	Phosphorylation	RGKSLKNSLKIKNVN CCCHHHHHHHCCCCC	29.47	29779826
949	Sumoylation	VEGQKLIKKEFVETG HHCCEEEEHHHHHCC	57.60	-
949	Sumoylation	VEGQKLIKKEFVETG HHCCEEEEHHHHHCC	57.60	-
1007	N-linked_Glycosylation	TSDSDNLNGTNNSSS CCCCCCCCCCCCCCC	62.59	-
1010	N-linked_Glycosylation	SDNLNGTNNSSSHRD CCCCCCCCCCCCCHH	48.02	-
1011	N-linked_Glycosylation	DNLNGTNNSSSHRDM CCCCCCCCCCCCHHH	43.01	-
1332	Phosphorylation	KVGVVGRTGAGKSSL EEEEEECCCCCHHHH	26.00	23984901
1384	Phosphorylation	PQDPILFSGSLRMNL CCCCCCCCCCCCCCC	24.83	30181290
1386	Phosphorylation	DPILFSGSLRMNLDP CCCCCCCCCCCCCCC	16.17	30181290
1434	Phosphorylation	TEGGDNLSIGQRQLL CCCCCCCCHHHHHHH	30.81	-
1525	Phosphorylation	LSNRGSFYLMAKEAG HCCCCCHHHHHHHHC	9.39	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRP2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHRF1_RAT	Slc9a3r1	physical	20404332

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.