| UniProt ID | MRO2B_HUMAN | |
|---|---|---|
| UniProt AC | Q7Z745 | |
| Protein Name | Maestro heat-like repeat-containing protein family member 2B {ECO:0000312|HGNC:HGNC:26857} | |
| Gene Name | MROH2B {ECO:0000312|HGNC:HGNC:26857} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1585 | |
| Subcellular Localization | Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Cell projection, cilium, flagellum . Colocalizes with PRKACA and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sp | |
| Protein Description | May play a role in the process of sperm capacitation.. | |
| Protein Sequence | MTLSTEESIEMFGDINLTLGMLNKEDIVNKEDIYSHLTSVIQNTDILDDAIVQRLIYYASKDMRDNNMLREIRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPDEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLAEDERMKGTFCIALEKFSKAIYKYVNHWRDFPYPRLDANRLSDKIFMLFWYIMEKWAPLASPMQTLSIVKAHGPTVSLLLHREDFRGYALGQVPWLLNQYKDKEIDFHVTQSLKQILTAAVLYDIGLPRSLRRSIFINLLQQICRAPEPPVKENEMKASSCFLILAHSNPGELMEFFDEQVRSNNEAIRVGILTLLRLAVNADEPRLRDHIISIERTVKIVMGDLSTKVRNSVLLLIQTMCEKSYIEAREGWPLIDYVFSQFATLNRNLEKPVKTNFHENEKEEESVRETSLEVLKTLDPLVIGMPQVLWPRILTFVVPAEYTEALEPLFSIIRILIMAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGELRGAGAIGLLKILPEIIHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQLTQDFKQQMGSYSNNSTEKKFLWKALGTTLACCQDSDFVNSQIKEFLTAPNQLGDQRQGITSILGYCAENHLDIVLKVLKTFQNQEKFFMNRCKSLFSGKKSLTKTDVMVIYGAVALHAPKKQLLSRLNQDIISQVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRDEPLDSLASPIRWKALIAIRYLSKLKPQLSLQDHLNILEENIRRLLPLPPLENLKSEGQTDKDKEHIQFLYERSMDALGKLLKTMMWDNVNAEDCQEMFNLLQMWLVSQKEWERERAFQITAKVLTNDIEAPENFKIGSLLGLLAPHSCDTLPTIRQAAASSTIGLFYIKGIHLEVERLQGLQEGLESDDVQVQIKISSKIAKIVSKFIPNEEILMFLEEMLDGLESLNPTCTKACGIWMITVLKQQGAALEDQLLEILGTIYHHMPVLRQKEESFQFILEAISQIASFHMDTVVVNLLQKPLPFDRDTKTLWKALAEKPASSGKLLQALIDKLETELEDDIARVEAISVACAMYEVISMGTSVTGLYPELFTLLLKLVSCTLGQKMLTCPWSHRRHVMQQGEQQQIPDPCRLSTATLKCLQAQAMREGLAKESDEGDNLWTLLSSPSTHHIGVCSLARSMAVWQHGVILDIMEQLLSSLTSSSENYRITGAAFFSELMKEPILWKHGNLRNVLILMDQSAWDSNATLRQMAIRGLGNTASGAPHKVKKHKQLMLESIIRGLYHLARTEVVCESLKALKKILELLTDRDVSFYFKEIVLQTRTFFEDEQDDVRLTAIFLFEDLAPLTGRRWKIFFAEEIKKSLISFLLHLWDPNPKIGVACRDVLMVCIPFLGLQELYGVLDRLLDQDLPRARDFYRQFCVKLAKKNQEILWILHTHSFTFFTSTWEVIRSAAVKLTDAVVLNLTSQYVELLDREQLTTRLQALRQDPCISVQRAAEAALQTLLRRCKETSIPL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 163 | Phosphorylation | EKFSKAIYKYVNHWR HHHHHHHHHHHHCCC | 27174698 | ||
| 165 | Phosphorylation | FSKAIYKYVNHWRDF HHHHHHHHHHCCCCC | 27174698 | ||
| 174 | Phosphorylation | NHWRDFPYPRLDANR HCCCCCCCCCCCHHH | 27174698 | ||
| 183 | Phosphorylation | RLDANRLSDKIFMLF CCCHHHHHHHHHHHH | 26329039 | ||
| 251 | Phosphorylation | KEIDFHVTQSLKQIL CCCCHHHHHHHHHHH | 23312004 | ||
| 253 | Phosphorylation | IDFHVTQSLKQILTA CCHHHHHHHHHHHHH | 23312004 | ||
| 324 | Phosphorylation | FFDEQVRSNNEAIRV HHHHHHHCCCHHHHH | - | ||
| 335 | Phosphorylation | AIRVGILTLLRLAVN HHHHHHHHHHHHHHC | - | ||
| 427 | Phosphorylation | ENEKEEESVRETSLE CCHHHHHHHHHHHHH | 29083192 | ||
| 431 | Phosphorylation | EEESVRETSLEVLKT HHHHHHHHHHHHHHH | 29083192 | ||
| 483 | Ubiquitination | ILIMAEEKKQHSAKE HHHHHHHHHHCCCCC | - | ||
| 484 | Ubiquitination | LIMAEEKKQHSAKES HHHHHHHHHCCCCCC | - | ||
| 491 | Phosphorylation | KQHSAKESTALVVST HHCCCCCCCEEEEEC | - | ||
| 492 | Phosphorylation | QHSAKESTALVVSTG HCCCCCCCEEEEECC | - | ||
| 497 | Phosphorylation | ESTALVVSTGAVKLP CCCEEEEECCCCCCC | - | ||
| 498 | Phosphorylation | STALVVSTGAVKLPS CCEEEEECCCCCCCC | - | ||
| 605 | Phosphorylation | FKQQMGSYSNNSTEK HHHHHCCCCCCHHHH | 23532336 | ||
| 606 | Phosphorylation | KQQMGSYSNNSTEKK HHHHCCCCCCHHHHH | 23532336 | ||
| 673 | Acetylation | DIVLKVLKTFQNQEK HHHHHHHHHHCCHHH | 18604499 | ||
| 680 | Acetylation | KTFQNQEKFFMNRCK HHHCCHHHHHHHHHH | 18604507 | ||
| 688 | Phosphorylation | FFMNRCKSLFSGKKS HHHHHHHHHHCCCCC | 27251275 | ||
| 691 | Phosphorylation | NRCKSLFSGKKSLTK HHHHHHHCCCCCCCH | 27251275 | ||
| 695 | Phosphorylation | SLFSGKKSLTKTDVM HHHCCCCCCCHHCHH | - | ||
| 697 | Phosphorylation | FSGKKSLTKTDVMVI HCCCCCCCHHCHHHH | - | ||
| 698 | Ubiquitination | SGKKSLTKTDVMVIY CCCCCCCHHCHHHHH | - | ||
| 699 | Phosphorylation | GKKSLTKTDVMVIYG CCCCCCHHCHHHHHH | 28270605 | ||
| 705 | Phosphorylation | KTDVMVIYGAVALHA HHCHHHHHHHHHHHC | 28270605 | ||
| 989 | Phosphorylation | VQVQIKISSKIAKIV CEEEEEHHHHHHHHH | 22964224 | ||
| 990 | Phosphorylation | QVQIKISSKIAKIVS EEEEEHHHHHHHHHH | 22964224 | ||
| 997 | Phosphorylation | SKIAKIVSKFIPNEE HHHHHHHHHHCCCHH | 22964224 | ||
| 1022 | Phosphorylation | GLESLNPTCTKACGI HHHHHCCHHHHHHCH | - | ||
| 1024 | Phosphorylation | ESLNPTCTKACGIWM HHHCCHHHHHHCHHH | - | ||
| 1110 | Ubiquitination | LWKALAEKPASSGKL HHHHHHHCCCCCCHH | - | ||
| 1171 | Phosphorylation | TLLLKLVSCTLGQKM HHHHHHHHCCCCCHH | - | ||
| 1348 | Phosphorylation | HKQLMLESIIRGLYH HHHHHHHHHHHHHHH | - | ||
| 1377 | Phosphorylation | KKILELLTDRDVSFY HHHHHHHCCCCHHHH | 23403867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MRO2B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MRO2B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MRO2B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MRO2B_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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