MRE11_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRE11_CAEEL
• UniProt AC: Q23255
• Protein Name: Double-strand break repair protein mre-11
• Gene Name: mre-11 {ECO:0000312|WormBase:ZC302.1}
• Organism: Caenorhabditis elegans.
• Sequence Length: 728
• Subcellular Localization: Nucleus .
• Protein Description: Involved in DNA double-strand break repair (DSBR). [PubMed: 11238374 Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity]
• Protein Sequence: MCGSDDSFDDFVPDSQEPASSRTRNQDHLDDDEVPCSQRPDAANDTMVEDLDEGDEPAHDESEDIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHENNPSREVQHRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHDDLSGKGLTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLVRAFKNNSISFLRPNAGAEDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGHEHECKPDPQYVASSEAVGDGFYILQPGSTVATSLTPEEALQKNAFLIKIKGRKFASKPIPLQTVRPMVCDELLLDKIPPGSRPILKTDRPKHTDGRYIDEIAIEAKINEMITTAKAKRRPRQPELPLIRLKVIYDGDWLNITPANAKRIGLRYENVVANAVDMVFIKKNNKPKEGKLQTENEKNITEMADEMGQVSATNLQTIINDYFINQPLVDQMTVLKPIGIGRALEQYSAIEEGGLATSANRNFDSCLMHQIDVVRKTLKKMPLPPINDPSDLDKFRDLITKDLYDMKKADSERFKNPVADVEMEEDEDDPQYYMPPQSTSRTNYASGSEDEVANSDEEMGSSISRHSKQPTTRGRGRGARGAGASRETTRGRSNKVVSTRQIDSDGFEIINDSPSPPPASRSTRGKARGKSAPSKKRDLSFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MCGSDDSFDDF ----CCCCCCCCCCC	33.06	30078680
7	Phosphorylation	-MCGSDDSFDDFVPD -CCCCCCCCCCCCCC	35.25	30078680
674	Phosphorylation	GAGASRETTRGRSNK CCCCCCCCCCCCCCC	22.23	19530675
675	Phosphorylation	AGASRETTRGRSNKV CCCCCCCCCCCCCCE	26.77	19530675
690	Phosphorylation	VSTRQIDSDGFEIIN EEEEEECCCCCEECC	41.06	30078680
699	Phosphorylation	GFEIINDSPSPPPAS CCEECCCCCCCCCCC	23.84	28854356
701	Phosphorylation	EIINDSPSPPPASRS EECCCCCCCCCCCCC	54.73	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRE11_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRE11_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRE11_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.