MRD1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRD1_SCHPO
• UniProt AC: O13620
• Protein Name: Multiple RNA-binding domain-containing protein 1
• Gene Name: mrd1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 833
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-rRNA processing..
• Protein Sequence: MSRIIIKNIPRYYDKEKLSTYLKSLPQLDAEITDVSVAKTKEGVSRRFAFIGFKNEEDADKAIRYLNKSYVETSRIEVHRALDYRSANEKLRPYSKYASKNIELKLQKKEKEEELRNLEEEKAKKKKDANLKRKFLDTLDPKAREFLKLSSSISNSRSWENEEVFDTEITNPVIPADEDDDEYQDLPAAKRHEGDSIKSTEHDSTLDSGVVIDGREKSSSELHEEESEQAAEGDTAKNSGTDAQAPLSDDEWLRLHRTRIKEKQPEEEVSVVGDELKSFDKENNDEHLERVTNDKIADASMLQKAENNVSEQERNIQLISETKRLFLRNLTYSCAEDDLKSLFGPFGQLEQVHMPIDKKTNNPKGFAYIDFHDADDAVRAYLELDAKPFQGRLLHVLPAKARSSILLDDYALSKLPLKKQRELKRKNTAASSTFSWNSLYMNADAVVTSLASRLGVKKTDILDPTSSDSAVKQALTETHVIQETKNFFEEHGVDLDAFKNAARSDNVLLVKNFPYGTSAEELTSLFSPFGELGRILIPPAGTIAIIEFLNAPDCRQAFSKLAYTRIKSSILYLEKAPRDVFTTSFKQSGKPELAQKVNAVEATTSEKVGTEDIESLDTATIYVKNLNFSTKQEEFQKVFKPLEGYLSAVIRAKPDPKRPGKYLSMGFGFVEFKDKASAVAAMHAMNGFVLDGHKLEIKLSHQGVDAAAEVRKQDSSKPKGTKILIKNLPFEATKKDVQSLLGAYGQLRSVRVPKKFDRSARGFAFAEFVTAREAANAMRALKNTHLLGRHLVLQYASNATMDDMQHAIEKMAKEANAEAAAPSITGKRLIETD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	YYDKEKLSTYLKSLP CCCHHHHHHHHHHCC	26.52	25720772
21	Phosphorylation	DKEKLSTYLKSLPQL CHHHHHHHHHHCCCC	14.57	25720772
196	Phosphorylation	AKRHEGDSIKSTEHD HHHCCCCCCCCCCCC	42.65	21712547
199	Phosphorylation	HEGDSIKSTEHDSTL CCCCCCCCCCCCCCC	37.04	21712547
200	Phosphorylation	EGDSIKSTEHDSTLD CCCCCCCCCCCCCCC	32.13	21712547
204	Phosphorylation	IKSTEHDSTLDSGVV CCCCCCCCCCCCCCE	32.55	21712547
205	Phosphorylation	KSTEHDSTLDSGVVI CCCCCCCCCCCCCEE	40.41	21712547
218	Phosphorylation	VIDGREKSSSELHEE EECCCCCCHHHCCHH	34.05	25720772
219	Phosphorylation	IDGREKSSSELHEEE ECCCCCCHHHCCHHH	38.61	25720772
220	Phosphorylation	DGREKSSSELHEEES CCCCCCHHHCCHHHH	51.79	25720772
227	Phosphorylation	SELHEEESEQAAEGD HHCCHHHHHHHHHCC	37.98	29996109
248	Phosphorylation	TDAQAPLSDDEWLRL CCCCCCCCHHHHHHH	41.79	29996109
270	Phosphorylation	KQPEEEVSVVGDELK CCCHHHCEECHHHHH	17.86	24763107
823	Phosphorylation	NAEAAAPSITGKRLI CHHHHCCCCCCCCCC	28.23	27738172
825	Phosphorylation	EAAAPSITGKRLIET HHHCCCCCCCCCCCC	40.77	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRD1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRD1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRD1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of MRD1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.