MPZL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPZL2_HUMAN
• UniProt AC: O60487
• Protein Name: Myelin protein zero-like protein 2
• Gene Name: MPZL2
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Mediates homophilic cell-cell adhesion..
• Protein Sequence: MYGKSSTRAVLLLLGIQLTALWPIAAVEIYTSRVLEAVNGTDARLKCTFSSFAPVGDALTVTWNFRPLDGGPEQFVFYYHIDPFQPMSGRFKDRVSWDGNPERYDASILLWKLQFDDNGTYTCQVKNPPDVDGVIGEIRLSVVHTVRFSEIHFLALAIGSACALMIIIVIVVVLFQHYRKKRWAERAHKVVEIKSKEEERLNQEKKVSVYLEDTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYGKSSTRA ------CCCCHHHHH	33.01	25072903
5	Phosphorylation	---MYGKSSTRAVLL ---CCCCHHHHHHHH	32.36	25072903
6	Phosphorylation	--MYGKSSTRAVLLL --CCCCHHHHHHHHH	25.96	25072903
7	Phosphorylation	-MYGKSSTRAVLLLL -CCCCHHHHHHHHHH	29.73	25072903
39	N-linked_Glycosylation	SRVLEAVNGTDARLK HHHHHHHCCCCCEEE	55.48	19159218
96	Phosphorylation	GRFKDRVSWDGNPER CCCCCCCCCCCCHHH	21.97	30257219
118	N-linked_Glycosylation	WKLQFDDNGTYTCQV EEEEECCCCEEEEEE	46.69	UniProtKB CARBOHYD
194	Ubiquitination	AHKVVEIKSKEEERL HHHEEEECCHHHHHH	41.80	-
195	Phosphorylation	HKVVEIKSKEEERLN HHEEEECCHHHHHHH	51.46	23312004
206	Ubiquitination	ERLNQEKKVSVYLED HHHHHCCCEEEEEEC	38.70	-
208	Phosphorylation	LNQEKKVSVYLEDTD HHHCCCEEEEEECCC	17.58	25159151
210	Phosphorylation	QEKKVSVYLEDTD-- HCCCEEEEEECCC--	9.25	28152594
214	Phosphorylation	VSVYLEDTD------ EEEEEECCC------	33.94	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPZL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPZL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPZL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP1M1_HUMAN	AP1M1	physical	26186194
OCLN_HUMAN	OCLN	physical	26186194

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-39, AND MASS SPECTROMETRY.
PubMed: 19159218