MPRIP_RAT - dbPTM
MPRIP_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPRIP_RAT
UniProt AC Q9ERE6
Protein Name Myosin phosphatase Rho-interacting protein
Gene Name Mprip
Organism Rattus norvegicus (Rat).
Sequence Length 1029
Subcellular Localization Cytoplasm, cytoskeleton. Colocalizes with F-actin..
Protein Description Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells (By similarity)..
Protein Sequence MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEARTGQKFSLCILTPDKEHFIRAETKEIISGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKMAVTSSSGGSSGSSSSSSSSSIPSAEKVPTTKSTLWQEEMRAKDQPDGTSLSPVQSPSQSQPPAACTPRETGLDSKEDENILSGDRVDGGRKVRVESGYFSLEKAKQDLRAEEQLPPLLSPPSPSTPHSRRSQVIEKFEALDIEKAEHMETNMLILTTPSSDTRQGRSERRAIPRKRDFASETPTAPLSDACPLSPHRRAKSLDRRSTESSMTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEINLSTCYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVLPTSAPDVTSSLPEGKNKSTSFDTCLRPSEKQEAEPGEPDPEQKKSRARERRREGRSKTFDWAEFRPIQQALAQERASTVGSSDSGDPGCLEAEPGELERERARRREERRKRFGMLDTNDGPGMEDTALRMDIDRSPGLLGTPDLKTQNVHVEIEQRWHQVETTPLREEKQVPIAPLHLSLEDRSERLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSINSDIEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTREGGGESTGLPLTQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPEGTTVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVSWDN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
148PhosphorylationWLEMLMVYPRTNKQN
HHHHHHHCCCCCCCC		3.50-
166PhosphorylationKRKVEPPTPQEPGPA
CCCCCCCCCCCCCCC		48.6028689409
180PhosphorylationAKMAVTSSSGGSSGS
CCEEEECCCCCCCCC		24.5216641100
187PhosphorylationSSGGSSGSSSSSSSS
CCCCCCCCCCCCCCC		29.0628689409
188PhosphorylationSGGSSGSSSSSSSSS
CCCCCCCCCCCCCCC		37.4516641100
190PhosphorylationGSSGSSSSSSSSSIP
CCCCCCCCCCCCCCC		35.8716641100
191PhosphorylationSSGSSSSSSSSSIPS
CCCCCCCCCCCCCCC		35.8716641100
192PhosphorylationSGSSSSSSSSSIPSA
CCCCCCCCCCCCCCC		35.8716641100
198PhosphorylationSSSSSIPSAEKVPTT
CCCCCCCCCCCCCCC		47.60-
223PhosphorylationAKDQPDGTSLSPVQS
HHCCCCCCCCCCCCC		33.6027097102
224PhosphorylationKDQPDGTSLSPVQSP
HCCCCCCCCCCCCCC		32.1727097102
226PhosphorylationQPDGTSLSPVQSPSQ
CCCCCCCCCCCCCCC		23.8523712012
230PhosphorylationTSLSPVQSPSQSQPP
CCCCCCCCCCCCCCC		27.1023712012
232PhosphorylationLSPVQSPSQSQPPAA
CCCCCCCCCCCCCCC		47.9423712012
234PhosphorylationPVQSPSQSQPPAACT
CCCCCCCCCCCCCCC		49.3327097102
241PhosphorylationSQPPAACTPRETGLD
CCCCCCCCCCCCCCC		22.2127097102
271PhosphorylationGRKVRVESGYFSLEK
CCEEEEEECEEEHHH		35.6222108457
273PhosphorylationKVRVESGYFSLEKAK
EEEEEECEEEHHHHH		10.1625575281
275PhosphorylationRVESGYFSLEKAKQD
EEEECEEEHHHHHHH		27.4327097102
294PhosphorylationEQLPPLLSPPSPSTP
HHCCCCCCCCCCCCC		42.3127097102
297PhosphorylationPPLLSPPSPSTPHSR
CCCCCCCCCCCCCCH		34.5623712012
299PhosphorylationLLSPPSPSTPHSRRS
CCCCCCCCCCCCHHH		59.9327097102
300PhosphorylationLSPPSPSTPHSRRSQ
CCCCCCCCCCCHHHH		28.5327097102
303PhosphorylationPSPSTPHSRRSQVIE
CCCCCCCCHHHHHHH		30.5027097102
306PhosphorylationSTPHSRRSQVIEKFE
CCCCCHHHHHHHHHH		27.9128432305
355PhosphorylationPRKRDFASETPTAPL
CCCCCCCCCCCCCCH		41.8325575281
357PhosphorylationKRDFASETPTAPLSD
CCCCCCCCCCCCHHH		24.3627097102
359PhosphorylationDFASETPTAPLSDAC
CCCCCCCCCCHHHCC		48.6123984901
363PhosphorylationETPTAPLSDACPLSP
CCCCCCHHHCCCCCH		23.3127097102
369PhosphorylationLSDACPLSPHRRAKS
HHHCCCCCHHHCCCC		12.1023712012
381PhosphorylationAKSLDRRSTESSMTP
CCCCCCCCCCCCCCH		37.1028432305
382PhosphorylationKSLDRRSTESSMTPD
CCCCCCCCCCCCCHH		37.7728432305
384PhosphorylationLDRRSTESSMTPDLL
CCCCCCCCCCCHHHH		26.0430181290
385PhosphorylationDRRSTESSMTPDLLN
CCCCCCCCCCHHHHH		22.0530181290
400UbiquitinationFKKGWLTKQYEDGQW
CCCEEEEEECCCCCE		49.03-
489PhosphorylationIMKHVLPTSAPDVTS
HHHHHCCCCCCCCHH		33.1027097102
490PhosphorylationMKHVLPTSAPDVTSS
HHHHCCCCCCCCHHC		35.5527097102
495PhosphorylationPTSAPDVTSSLPEGK
CCCCCCCHHCCCCCC		21.7025575281
496PhosphorylationTSAPDVTSSLPEGKN
CCCCCCHHCCCCCCC		29.7130181290
497PhosphorylationSAPDVTSSLPEGKNK
CCCCCHHCCCCCCCC		38.28-
505PhosphorylationLPEGKNKSTSFDTCL
CCCCCCCCCCCCCCC		38.3828432305
506PhosphorylationPEGKNKSTSFDTCLR
CCCCCCCCCCCCCCC		34.7128432305
507PhosphorylationEGKNKSTSFDTCLRP
CCCCCCCCCCCCCCH		28.3728432305
543PhosphorylationERRREGRSKTFDWAE
HHHHHHHCCCCCHHH		47.0727097102
545PhosphorylationRREGRSKTFDWAEFR
HHHHHCCCCCHHHHH		28.2427097102
622PhosphorylationLRMDIDRSPGLLGTP
HHEECCCCCCCCCCC		21.4123712012
628PhosphorylationRSPGLLGTPDLKTQN
CCCCCCCCCCCCCCC		17.3822108457
650PhosphorylationRWHQVETTPLREEKQ
HHEECCCCCCCCCCC		13.56-
666PhosphorylationPIAPLHLSLEDRSER
CCCCEECCHHHHHHH		20.9728432305
671PhosphorylationHLSLEDRSERLSTHE
ECCHHHHHHHCCHHH		39.1128432305
675PhosphorylationEDRSERLSTHELTSL
HHHHHHCCHHHHHHH		33.6622108457
676PhosphorylationDRSERLSTHELTSLL
HHHHHCCHHHHHHHH		24.7828432305
680PhosphorylationRLSTHELTSLLEKEL
HCCHHHHHHHHHHHH		17.8425575281
681PhosphorylationLSTHELTSLLEKELE
CCHHHHHHHHHHHHH		43.5125575281
804PhosphorylationSQISSINSDIEALRR
HHHHHHHHHHHHHHH		37.99-
949PhosphorylationSDKYKDIYTELSIAK
CHHHHHHHHHHHHHH		12.3330181290
950PhosphorylationDKYKDIYTELSIAKA
HHHHHHHHHHHHHHH		30.6830181290
953PhosphorylationKDIYTELSIAKAKAD
HHHHHHHHHHHHHCC		17.8030181290
958AcetylationELSIAKAKADCDISR
HHHHHHHHCCCCHHH		44.0122902405
974PhosphorylationKEQLKAATEALGEKS
HHHHHHHHHHHCCCC		27.0125403869
981PhosphorylationTEALGEKSPEGTTVS
HHHHCCCCCCCCEEC		24.7130240740
985PhosphorylationGEKSPEGTTVSGYDI
CCCCCCCCEECHHHH		23.5125403869
986PhosphorylationEKSPEGTTVSGYDIM
CCCCCCCEECHHHHH		24.4325403869
988PhosphorylationSPEGTTVSGYDIMKS
CCCCCEECHHHHHCC		29.5523984901
990PhosphorylationEGTTVSGYDIMKSKS
CCCEECHHHHHCCCC		8.5223984901
995PhosphorylationSGYDIMKSKSNPDFL
CHHHHHCCCCCCCHH		24.7616396499
997PhosphorylationYDIMKSKSNPDFLKK
HHHHCCCCCCCHHHC		61.7623712012
1018PhosphorylationRQLRNIRSKSVIEQV
HHHHHHHCCHHHHHC		26.0327097102
1020PhosphorylationLRNIRSKSVIEQVSW
HHHHHCCHHHHHCCC		29.5829779826
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPRIP_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPRIP_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPRIP_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MPRIP_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPRIP_RAT

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-188; SER-190;SER-191; SER-192; THR-223; SER-226; SER-230 AND SER-232, AND MASSSPECTROMETRY.

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