MPPA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPPA_MOUSE
• UniProt AC: Q9DC61
• Protein Name: Mitochondrial-processing peptidase subunit alpha
• Gene Name: Pmpca
• Organism: Mus musculus (Mouse).
• Sequence Length: 524
• Subcellular Localization: Mitochondrion matrix . Mitochondrion inner membrane .
• Protein Description: Cleaves presequences (transit peptides) from mitochondrial protein precursors..
• Protein Sequence: MATAVWAAARLLRGSAVLCARPRFGSPAHRRFSSGATYPNIPLSSPLPGVPKPIFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVDLLADVVLHPRLTDEEIEMTRMAVQFELEDLNMRPDPEPLLTEMIHEAAFRENTVGLHRFCPVENIAKIDREVLHSYLKNYYTPDRMVLAGVGVEHEHLVECARKYLVGAEPAWGAPGTVDVDRSVAQYTGGIIKVERDMSNVSLGPTPIPELTHIMVGLESCSFLEDDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGRTVDLVELERAKTQLMSMLMMNLESRPVIFEDVGRQVLATHSRKLPHELCTLIRNVKPEDIKRVASKMLRGKPAVAALGDLTDLPTYEHIQAALSSRNGHLPRSYRLFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	SPAHRRFSSGATYPN CCCHHCCCCCCCCCC	26.50	26643407
34	Phosphorylation	PAHRRFSSGATYPNI CCHHCCCCCCCCCCC	29.72	26643407
37	Phosphorylation	RRFSSGATYPNIPLS HCCCCCCCCCCCCCC	42.93	26643407
63	Succinylation	ATVDGQEKFETKVTT EEECCCCCEEEEEEE	40.38	-
63	Succinylation	ATVDGQEKFETKVTT EEECCCCCEEEEEEE	40.38	23806337
63	Acetylation	ATVDGQEKFETKVTT EEECCCCCEEEEEEE	40.38	23806337
67	Acetylation	GQEKFETKVTTLDNG CCCCEEEEEEECCCC	30.32	23806337
67	Succinylation	GQEKFETKVTTLDNG CCCCEEEEEEECCCC	30.32	23806337
87	S-palmitoylation	QNKFGQFCTVGILIN CCCCCCCEEEEEEEC	2.01	26165157
117	Phosphorylation	FLEKLAFSSTARFDS HHHHHHCCCCCCCCC	22.60	25619855
118	Phosphorylation	LEKLAFSSTARFDSK HHHHHCCCCCCCCCC	21.45	25619855
119	Phosphorylation	EKLAFSSTARFDSKD HHHHCCCCCCCCCCC	22.21	25619855
240	Phosphorylation	DREVLHSYLKNYYTP CHHHHHHHHHHCCCC	15.79	28576409
265	S-nitrosocysteine	EHEHLVECARKYLVG CHHHHHHHHHHHHHC	3.28	-
265	S-nitrosylation	EHEHLVECARKYLVG CHHHHHHHHHHHHHC	3.28	21278135
298	Acetylation	QYTGGIIKVERDMSN HHCCCEEEEEECCCC	35.80	23576753
298	Succinylation	QYTGGIIKVERDMSN HHCCCEEEEEECCCC	35.80	23806337
450	Methylation	VIFEDVGRQVLATHS EEEEHHHHHHHHHCC	24.23	58859059
459	Acetylation	VLATHSRKLPHELCT HHHHCCCCCCHHHHH	70.19	22826441
465	S-nitrosocysteine	RKLPHELCTLIRNVK CCCCHHHHHHHHCCC	2.37	-
465	Glutathionylation	RKLPHELCTLIRNVK CCCCHHHHHHHHCCC	2.37	24333276
465	S-nitrosylation	RKLPHELCTLIRNVK CCCCHHHHHHHHCCC	2.37	21278135
472	Acetylation	CTLIRNVKPEDIKRV HHHHHCCCHHHHHHH	46.36	23201123
477	Succinylation	NVKPEDIKRVASKML CCCHHHHHHHHHHHH	53.81	23954790
477	Acetylation	NVKPEDIKRVASKML CCCHHHHHHHHHHHH	53.81	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPPA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPPA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPPA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MPPA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.