MPK5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPK5_ARATH
• UniProt AC: Q39025
• Protein Name: Mitogen-activated protein kinase 5
• Gene Name: MPK5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 376
• Protein Sequence: MAKEIESATDLGDTNIKGVLVHGGRYFQYNVYGNLFEVSNKYVPPIRPIGRGAYGFVCAAVDSETHEEIAIKKIGKAFDNKVDAKRTLREIKLLRHLEHENVVVIKDIIRPPKKEDFVDVYIVFELMDTDLHQIIRSNQSLNDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNSNCDLKITDFGLARTTSETEYMTEYVVTRWYRAPELLLNSSEYTSAIDVWSVGCIFAEIMTREPLFPGKDYVHQLKLITELIGSPDGASLEFLRSANARKYVKELPKFPRQNFSARFPSMNSTAIDLLEKMLVFDPVKRITVEEALCYPYLSALHDLNDEPVCSNHFSFHFEDPSSTEEEIKELVWLESVKFNPLPSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
201	Phosphorylation	TSETEYMTEYVVTRW CCCCHHHHHHHHHHC	24.22	-
203	Phosphorylation	ETEYMTEYVVTRWYR CCHHHHHHHHHHCCC	7.34	-
206	Phosphorylation	YMTEYVVTRWYRAPE HHHHHHHHHCCCCCH	12.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPK5_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
201	T	Phosphorylation	Dually phosphorylated on Thr-201 and Tyr-203, which activates the enzyme.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPK5_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MPK5_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.