dbPTM

MPK16_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPK16_ARATH
UniProt AC	Q8W4J2
Protein Name	Mitogen-activated protein kinase 16
Gene Name	MPK16
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	567
Subcellular Localization
Protein Description
Protein Sequence	MQPDHRKKSSVEVDFFTEYGEGSRYRIEEVIGKGSYGVVCSAYDTHTGEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHILLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLRGLKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFNDTPTAIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAELLTGKPLFPGKNVVHQLDLMTDMLGTPSAEAIGRVRNEKARRYLSSMRKKKPIPFSHKFPHTDPLALRLLEKMLSFEPKDRPTAEEALADVYFKGLAKVEREPSAQPVTKLEFEFERRRITKEDVRELIYRESLEYHPKMLKEYLDGSEPTNFMYPSAVEHFKKQFAYLEEHYKNGTSHNPPERQQHASLPRACVLYSDNNHPVAQQSSAEVTDGLSKCSIRDERPRGADRNAQMPMSRIPINVPQTIQGAAVARPGKVVGSVLRYNNCGAATGVEALEQQQRRMVRNPAAASQYPKRTQPCKSNRGDEDCATAAEGPSRLKPNTQYIPQKVSAAQDTAMSRWY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
182	Phosphorylation	VAFNDTPTAIFWTDY EECCCCCCEEEEEHH	34.18	23776212
187	Phosphorylation	TPTAIFWTDYVATRW CCCEEEEEHHHHCCC	13.50	30291188
189	Phosphorylation	TAIFWTDYVATRWYR CEEEEEHHHHCCCCC	5.66	30291188
192	Phosphorylation	FWTDYVATRWYRAPE EEEHHHHCCCCCCHH	16.22	23776212
412	Phosphorylation	PERQQHASLPRACVL HHHHHCCCCCCEEEE	36.46	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MPK16_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
187	T	Phosphorylation		28848569
Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPK16_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MPK16_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPK16_ARATH

Related Literatures of Post-Translational Modification