MPIP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPIP3_MOUSE
• UniProt AC: P48967
• Protein Name: M-phase inducer phosphatase 3
• Gene Name: Cdc25c
• Organism: Mus musculus (Mouse).
• Sequence Length: 447
• Subcellular Localization: Nucleus.
• Protein Description: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). May be involved in regulating the proliferation of T-lymphocytes following cytokine stimulation..
• Protein Sequence: MSTGPIPPASEEGSFVSAPSFRSKQRKILHLLLERNTSFTIRSDFPESPKDKLHDSANLSILSGGTPKCCLDLSNLSSGEMSASPLTTSADLEDNGSLDSSGPLDRQLTGKDFHQDLMKGIPVQLLCSTPNAMNHGHRKKIAKRSTSAHKENINTSLKALEWEAPRTPRFRKMPGGPLTSPLCELEMKHLGSPITTVPKLSQNVKLEDQERISEDPMECSLGDQDAKGLSLRKMVPLCDMNAIQMEEEESGSELLIGDFSKVCVLPTVPGKHPDLKYISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLHSQKELHEFFLRKPVVPLDIQKRVIIVFLCEFSSERGPRMCRSLREKDRALNQYPALYYPELYILKGGYRDFFPEYMELCDPQSYCPMLHQDHQAELLSWRSQSKAQEGERQLQGQIALLVKGASPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTGPIPPA ------CCCCCCCCC	41.91	-
2	Phosphorylation	------MSTGPIPPA ------CCCCCCCCC	41.91	25168779
3	Phosphorylation	-----MSTGPIPPAS -----CCCCCCCCCC	45.75	25168779
10	Phosphorylation	TGPIPPASEEGSFVS CCCCCCCCCCCCCCC	41.79	25168779
14	Phosphorylation	PPASEEGSFVSAPSF CCCCCCCCCCCCCCH	26.25	25168779
17	Phosphorylation	SEEGSFVSAPSFRSK CCCCCCCCCCCHHHH	32.24	25168779
20	Phosphorylation	GSFVSAPSFRSKQRK CCCCCCCCHHHHHHH	32.77	-
37	Phosphorylation	HLLLERNTSFTIRSD HHHHHCCCCEEECCC	31.29	28066266
38	Phosphorylation	LLLERNTSFTIRSDF HHHHCCCCEEECCCC	24.76	28066266
40	Phosphorylation	LERNTSFTIRSDFPE HHCCCCEEECCCCCC	18.43	28066266
48	Phosphorylation	IRSDFPESPKDKLHD ECCCCCCCCCCCCCC	37.17	25266776
56	Phosphorylation	PKDKLHDSANLSILS CCCCCCCCCCEEHHC	14.33	-
60	Phosphorylation	LHDSANLSILSGGTP CCCCCCEEHHCCCCC	22.69	-
63	Phosphorylation	SANLSILSGGTPKCC CCCEEHHCCCCCCEE	33.24	-
66	Phosphorylation	LSILSGGTPKCCLDL EEHHCCCCCCEEEEC	24.09	-
128	Phosphorylation	IPVQLLCSTPNAMNH CCCEEEECCCCCCCC	47.04	-
129	Phosphorylation	PVQLLCSTPNAMNHG CCEEEECCCCCCCCC	21.40	-
143	Ubiquitination	GHRKKIAKRSTSAHK CHHHHHHHHCCHHHH	50.81	-
150	Ubiquitination	KRSTSAHKENINTSL HHCCHHHHHHHHHHH	52.77	-
156	Phosphorylation	HKENINTSLKALEWE HHHHHHHHHHHHHCC	24.31	27841257
167	Phosphorylation	LEWEAPRTPRFRKMP HHCCCCCCCCCCCCC	20.11	29514104
179	Phosphorylation	KMPGGPLTSPLCELE CCCCCCCCCCHHHHH	31.28	26643407
180	Phosphorylation	MPGGPLTSPLCELEM CCCCCCCCCHHHHHH	24.45	26643407
192	Phosphorylation	LEMKHLGSPITTVPK HHHHHCCCCCCCCCH	21.35	25266776
195	Phosphorylation	KHLGSPITTVPKLSQ HHCCCCCCCCCHHHC	25.73	28066266
196	Phosphorylation	HLGSPITTVPKLSQN HCCCCCCCCCHHHCC	35.21	26643407
213	Phosphorylation	LEDQERISEDPMECS CCCHHHHCCCCCCCC	42.01	-
220	Phosphorylation	SEDPMECSLGDQDAK CCCCCCCCCCCCCCC	23.29	28066266
230	Phosphorylation	DQDAKGLSLRKMVPL CCCCCCCCHHHHHHC	34.49	-
293	Phosphorylation	LLSGKFQSVIERFYI HHCCCHHHHHHEEEE	28.35	23737553
445	Phosphorylation	ALLVKGASPQ----- HHHHCCCCCC-----	32.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	T	Phosphorylation	Kinase	CDK1	P11440	Uniprot
192	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
213	S	Phosphorylation	Kinase	PLK3	Q60806	Uniprot
220	S	Phosphorylation	Kinase	PLK3	Q60806	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
213	S	Phosphorylation	Phosphorylation by PLK3 at Ser-213 promotes nuclear translocation.	-
220	S	Phosphorylation	Ser-220 is a minor phosphorylation site (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPIP3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MPIP3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.