MOT5_HUMAN - dbPTM
MOT5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MOT5_HUMAN
UniProt AC O15374
Protein Name Monocarboxylate transporter 5
Gene Name SLC16A4
Organism Homo sapiens (Human).
Sequence Length 487
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)..
Protein Sequence MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationREGKVQPYTKTLDGG
CCCCCCCCEEEECCC		12.08-
12PhosphorylationEGKVQPYTKTLDGGW
CCCCCCCEEEECCCC		25.00-
99UbiquitinationLGAFVVTGGYLISSW
HHEEEECCCHHHHHH		15.9033845483
128UbiquitinationPGLGSAFLYQVAAVV
CCCHHHHHHHHHHHH		2.6733845483
134UbiquitinationFLYQVAAVVTTKYFK
HHHHHHHHHHHHHHH		2.5733845483
140UbiquitinationAVVTTKYFKKRLALS
HHHHHHHHHHHHHHH		8.8433845483
147UbiquitinationFKKRLALSTAIARSG
HHHHHHHHHHHHHHC		15.3633845483
147PhosphorylationFKKRLALSTAIARSG
HHHHHHHHHHHHHHC		15.36-
148PhosphorylationKKRLALSTAIARSGM
HHHHHHHHHHHHHCC		23.96-
158PhosphorylationARSGMGLTFLLAPFT
HHHCCCHHHHHHHHH		13.40-
161UbiquitinationGMGLTFLLAPFTKFL
CCCHHHHHHHHHHHH		5.0633845483
164UbiquitinationLTFLLAPFTKFLIDL
HHHHHHHHHHHHHHH		10.9033845483
165PhosphorylationTFLLAPFTKFLIDLY
HHHHHHHHHHHHHHC		21.5927134283
166AcetylationFLLAPFTKFLIDLYD
HHHHHHHHHHHHHCC		38.2530586345
176UbiquitinationIDLYDWTGALILFGA
HHHCCHHHHHHHHHH		17.7133845483
182UbiquitinationTGALILFGAIALNLV
HHHHHHHHHHHHHCC		16.7833845483
188UbiquitinationFGAIALNLVPSSMLL
HHHHHHHCCCHHHHC		6.6133845483
190UbiquitinationAIALNLVPSSMLLRP
HHHHHCCCHHHHCCE		24.6933845483
196UbiquitinationVPSSMLLRPIHIKSE
CCHHHHCCEEEEECC		24.9433845483
202UbiquitinationLRPIHIKSENNSGIK
CCEEEEECCCCCCCC		44.9833845483
209UbiquitinationSENNSGIKDKGSSLS
CCCCCCCCCCCCCCC		57.8433845483
211UbiquitinationNNSGIKDKGSSLSAH
CCCCCCCCCCCCCCC		56.54-
212UbiquitinationNSGIKDKGSSLSAHG
CCCCCCCCCCCCCCC		32.3833845483
213PhosphorylationSGIKDKGSSLSAHGP
CCCCCCCCCCCCCCC		33.5728857561
214PhosphorylationGIKDKGSSLSAHGPE
CCCCCCCCCCCCCCC		34.7028857561
216PhosphorylationKDKGSSLSAHGPEAH
CCCCCCCCCCCCCCC		21.8428857561
226UbiquitinationGPEAHATETHCHETE
CCCCCCCCCCCCCCC		37.0233845483
238UbiquitinationETEESTIKDSTTQKA
CCCCCCCCCCCCCCC		45.7929901268
244UbiquitinationIKDSTTQKAGLPSKN
CCCCCCCCCCCCCCC		42.1829901268
249PhosphorylationTQKAGLPSKNLTVSQ
CCCCCCCCCCCEECC		38.9424719451
250UbiquitinationQKAGLPSKNLTVSQN
CCCCCCCCCCEECCC		54.7829901268
253PhosphorylationGLPSKNLTVSQNQSE
CCCCCCCEECCCCCH		27.7529978859
255PhosphorylationPSKNLTVSQNQSEEF
CCCCCEECCCCCHHH		20.4129978859
259PhosphorylationLTVSQNQSEEFYNGP
CEECCCCCHHHHCCC		46.7929978859
263PhosphorylationQNQSEEFYNGPNRNR
CCCCHHHHCCCCCCC		23.6129978859
274UbiquitinationNRNRLLLKSDEESDK
CCCCEEEECCHHHHH		56.6929901268
279PhosphorylationLLKSDEESDKVISWS
EEECCHHHHHHEECH		40.4628857561
341PhosphorylationMDASYLVSVAGILET
CCHHHHHHHHHHHHH		12.03-
354PhosphorylationETVSQIISGWVADQN
HHHHHHHHHHHCCCC		28.38-
364 (in isoform 4)Phosphorylation-38.60-
364PhosphorylationVADQNWIKKYHYHKS
HCCCCHHHHHHCCHH		38.60-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MOT5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MOT5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MOT5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MOT5_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MOT5_HUMAN

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Related Literatures of Post-Translational Modification

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