dbPTM

MOT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MOT1_SCHPO
UniProt AC	O43065
Protein Name	Probable helicase mot1
Gene Name	mot1 {ECO:0000312\|PomBase:SPBC1826.01c}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1953
Subcellular Localization	Nucleus . Localized on chromatin.
Protein Description	Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its ATPase activity (By similarity)..
Protein Sequence	MTTRLDRLVVLLDSGSTSVVRETAAKQIGDIQKVHPDELYNLLGRVVPYLKSKNWDTRVAAAKAIGGIVENVPVWNPNRTSPVKKEETEDLPSFNGDTEEKPFIKTEEGAPASSQSQVVVSSNLTSNSEVSKLEEERLSTRSHSQEIKPIVDFGPDEETAKELNTELKGKFENSLLSFESFDIANVLKAGKKLLGSASRDYDVNPANYSTHYLQQLSNLKSRLDLAGEYLDDSIMNDLGDNVGSNSKGSPTTSIPEHKTSINNNKPEDTPTPSENVHLSARQRNALKRKARQMKNSQKVRVIDVAPTLVHQQNSTSSADKKTGADYNFTAQSRSDRLVVEHKAPIVPSAAVAVTSDSVWPFETLVELLLIDMFDPSWEIRHGACMGLREIIRYAGFGYGRVVGKSEAENEQLNKKYFDDLLCRIACVFALDRFGDYLADQVVAPIRESVSQVLGVALIYVPNDSVFSMYKVLHSLVFQNELGLTNTVWEAAHGGMLGIKYLVAVKYPLFFSHSDYLDSLINTVIHGLANHDDDVRAVSALTLLPIADKLVQEKLSSCKNLLKVLWDCLDDVKDDLSSSTSCVMDLLSSLCSFTEVMNLMQETANSDPEFSFETLVPRLFHLMRYTLTGVRRSVVYALTKFISVQTSCSWITGLTLRLCFQNVLLEQQEDISKSSCELAQRVMDILYRDGPESFSKLLYSHIEPMLKVSITPIGSFRRPYPLDTTLIVKPSGQPYAPSTSRERNNNISELSNSRTKHRAKDDPKGSFCFSVDEPMLNGDVEFVGEERMLKARLRASSLLGRIIGRWKRDEILLFFKPFLQACLTSSFSTPVVLGSRLIESFFEVEDNDLTIQKDELYHLLCDQFATVPRENYANLVSQLHVVRAQCNALLNTFLDVGRLSRSKIPSLAVVVKGDPEAGPIAFGIADAEKLVGPTYENLCKLLSPSQKAQSSKALNEIKYLIIDEISIYKIAKERQDIQCSASIASAMVTYDKLPKKLNSIIKGIMESIKKEQFSCLQMHSASAMMKLISACYKESRQVISEKIVRNLCAYVCMDTTETPIFHDSGKNGILSLHSIGTSDDNDEQVSGKLVDDSDDVSNDRKSSLSSVSDKDAAVLQRMGAQLTLQQMAQNFGSSLFSRVPVLSQCLFVPLQQYAESGFPSEVDQASCTVGQDLLDAMSILRFLVAYLDSGLQSEIVSTLPHLLATLQSNYSAVRNMASKCFAAITESNAAGSKALHLLVEDVVPLLGDASSTIHRQGAIECIYHVVQRLGVRILPYILYLIIPLLGRMSDADQDVRVLATTSFATLVKLVPLEAGLPDPPDLPQYLLDSREKERKFLEQMLNPSKVEAFSIPVPISADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHYNRQKLFEESGSPKFAHVPSLIVCPSTLAGHWQQELSTYAPFLKVSAYVGPPAERAKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHKQVLPFMLRRLKEDVLADLPPKIIQDYYCDMSDLQRKLLNDFVSQLNINEELEDDETEKTQGTRKKKSQKAHIFQALQYMRKLCNHPALILTEKHPKRNAIVKQLAKENSGLHDLKHAPKLTALGQLLRDCGLGNSSVNSNGIDSALTNAVSEHRVLIFCQLKDMLDMVEKDLLQATMPDVTYMRLDGSVEPTKRQEAVTKFNNDPSIDVLLLTTHVGGLGLNLTGADTVIFVEHDWNPMRDLQAMDRAHRIGQKKVVNVYRLITRGCLEEKIMGLQRFKMNVASTVVNQQNAGLSSIGTDQILDLFNTTADEQQTVQNIDKEESEDAAGRGLSGTSKKALEGLPEMWDESQYDEFNLDGFISTLPKDAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	RVVPYLKSKNWDTRV HHHHHHHCCCHHHHH	28.73	21712547
81	Phosphorylation	VWNPNRTSPVKKEET CCCCCCCCCCCHHHC	25.18	21712547
93	Phosphorylation	EETEDLPSFNGDTEE HHCCCCCCCCCCCCC	38.34	24763107
144	Phosphorylation	RLSTRSHSQEIKPIV HHHCCCCCCCCCCCC	30.65	28889911
221	Phosphorylation	QQLSNLKSRLDLAGE HHHHCHHHHHHHHHH	41.04	21712547
244	Phosphorylation	DLGDNVGSNSKGSPT HCCCCCCCCCCCCCC	33.38	24763107
246	Phosphorylation	GDNVGSNSKGSPTTS CCCCCCCCCCCCCCC	39.84	21712547
249	Phosphorylation	VGSNSKGSPTTSIPE CCCCCCCCCCCCCCC	23.86	28889911
251	Phosphorylation	SNSKGSPTTSIPEHK CCCCCCCCCCCCCCC	34.57	21712547
252	Phosphorylation	NSKGSPTTSIPEHKT CCCCCCCCCCCCCCC	28.22	29996109
253	Phosphorylation	SKGSPTTSIPEHKTS CCCCCCCCCCCCCCC	38.33	24763107
1092	Phosphorylation	SGKLVDDSDDVSNDR CCEECCCCCCCCCCC	31.11	25720772
1096	Phosphorylation	VDDSDDVSNDRKSSL CCCCCCCCCCCHHCC	39.75	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MOT1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MOT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MOT1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MOT1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MOT1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, AND MASSSPECTROMETRY.	18257517 [Abstract]