MOT1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOT1_RAT
• UniProt AC: P53987
• Protein Name: Monocarboxylate transporter 1
• Gene Name: Slc16a1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 494
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis..
• Protein Sequence: MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
210	Phosphorylation	GKVEKLKSKESLQEA CHHHHHCCHHHHHHH	52.68	23991683
213	Phosphorylation	EKLKSKESLQEAGKS HHHCCHHHHHHHCCC	38.80	23991683
219	Ubiquitination	ESLQEAGKSDANTDL HHHHHHCCCCCCCCC	52.81	-
220	Phosphorylation	SLQEAGKSDANTDLI HHHHHCCCCCCCCCC	40.83	23991683
224	Phosphorylation	AGKSDANTDLIGGSP HCCCCCCCCCCCCCC	33.62	23991683
230	Phosphorylation	NTDLIGGSPKGEKLS CCCCCCCCCCCCCCC	20.44	27097102
232	Ubiquitination	DLIGGSPKGEKLSVF CCCCCCCCCCCCCHH	79.84	-
455	Succinylation	EEKKRDGKEDETSTD HHHHCCCCCCCCCCC	67.30	26843850
459	Phosphorylation	RDGKEDETSTDVDEK CCCCCCCCCCCCCCC	49.61	23991683
460	Phosphorylation	DGKEDETSTDVDEKP CCCCCCCCCCCCCCC	22.14	23991683
461	Phosphorylation	GKEDETSTDVDEKPK CCCCCCCCCCCCCCC	47.68	29779826
466	Succinylation	TSTDVDEKPKKTMKE CCCCCCCCCCCCCCC	58.64	26843850
474	Phosphorylation	PKKTMKETQSPAPLQ CCCCCCCCCCCCCCC	28.91	27097102
476	Phosphorylation	KTMKETQSPAPLQNS CCCCCCCCCCCCCCC	30.37	27097102
483	Phosphorylation	SPAPLQNSSGDPAEE CCCCCCCCCCCCCCC	23.80	29779826
484	Phosphorylation	PAPLQNSSGDPAEEE CCCCCCCCCCCCCCC	55.56	27097102
492	Phosphorylation	GDPAEEESPV----- CCCCCCCCCC-----	33.95	23991683

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOT1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOT1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOT1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MOT1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.";
Moser K., White F.M.;
J. Proteome Res. 5:98-104(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210 AND SER-213, ANDMASS SPECTROMETRY.
PubMed: 16396499