MOC2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOC2B_HUMAN
• UniProt AC: O96007
• Protein Name: Molybdopterin synthase catalytic subunit {ECO:0000255|HAMAP-Rule:MF_03052}
• Gene Name: MOCS2 {ECO:0000255|HAMAP-Rule:MF_03052}
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group..
• Protein Sequence: MSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKDMDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKECFWASNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSLEISSS ------CCCCEECCC	43.56	25159151
3	Phosphorylation	-----MSSLEISSSC -----CCCCEECCCC	28.82	25159151
7	Phosphorylation	-MSSLEISSSCFSLE -CCCCEECCCCEECE	13.56	28122231
8	Phosphorylation	MSSLEISSSCFSLET CCCCEECCCCEECEE	36.47	28122231
9	Phosphorylation	SSLEISSSCFSLETK CCCEECCCCEECEEC	16.64	28122231
12	Phosphorylation	EISSSCFSLETKLPL EECCCCEECEECCCC	29.62	28122231
15	Phosphorylation	SSCFSLETKLPLSPP CCCEECEECCCCCCC	43.08	26074081
20	Phosphorylation	LETKLPLSPPLVEDS CEECCCCCCCCCCCC	23.64	29255136
27	Phosphorylation	SPPLVEDSAFEPSRK CCCCCCCCCCCCCCC	22.73	29632367
32	Phosphorylation	EDSAFEPSRKDMDEV CCCCCCCCCCCHHHH	44.77	23927012
89	Phosphorylation	FEGKKVISLEYEAYL CCCCEEEEEEEEECC	20.38	25072903
92	Phosphorylation	KKVISLEYEAYLPMA CEEEEEEEEECCHHC	15.91	25072903
95	Phosphorylation	ISLEYEAYLPMAENE EEEEEEECCHHCHHH	10.21	25072903
153	Phosphorylation	ASLEAVSYAIDTLKA HHHHHHHHHHHHHHH	10.85	20068231
157	Phosphorylation	AVSYAIDTLKAKVPI HHHHHHHHHHHCCCE	24.85	20068231
170	Phosphorylation	PIWKKEIYEESSTWK CEECHHHHCCCCCCC	18.09	-
180	Ubiquitination	SSTWKGNKECFWASN CCCCCCCCCCEEECC	65.61	-
188	Phosphorylation	ECFWASNS------- CCEEECCC-------	38.82	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOC2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOC2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOC2B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MOC2B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 252160: Molybdenum cofactor deficiency, complementation group B (MOCODB)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.
PubMed: 18691976

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.
PubMed: 16964243